5FN2: Cryo-EM structure of gamma secretase in complex with a drug DAPT

PDB ID: 5FN2Download
MMDB ID: 145921
PDB Deposition Date: 2015/11/10
Updated in MMDB: 2016/12
Experimental Method:
electron microscopy
Resolution: 4.2  Å
Source Organism:
Similar Structures:
Molecular Components in 5FN2
Label Count Molecule
Proteins (4 molecules)
1
Nicastrin
(Gene symbol: NCSTN)
Molecule annotation
1
Presenilin-1
(Gene symbol: PSEN1)
Molecule annotation
1
Gamma-secretase Subunit Aph-1a
(Gene symbol: APH1A)
Molecule annotation
1
Gamma-secretase Subunit Pen-2
(Gene symbol: PSENEN)
Molecule annotation
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303