5FZA: Crystal structure of the catalytic domain of human JARID1B in complex with 3D fragment 2-piperidin-4-yloxy-5-(trifluoromethyl)pyridine (N10072a) (ligand modelled based on PANDDA event map)

PDB ID: 5FZADownload
MMDB ID: 137958
PDB Deposition Date: 2016/3/12
Updated in MMDB: 2016/04
Experimental Method:
x-ray diffraction
Resolution: 2.099  Å
Source Organism:
Similar Structures:
Biological Unit for 5FZA: monomeric; determined by author and by software (PISA)
Molecular Components in 5FZA
Label Count Molecule
Protein (1 molecule)
1
Lysine-specific Demethylase 5B
(Gene symbol: KDM5B)
Molecule annotation
Chemicals and Non-standard biopolymers (19 molecules)
1
2
ZINC IONZINC ION
2
1
CHLORIDE IONCHLORIDE ION
3
1
MANGANESE (II) IONMANGANESE (II) ION
4
1
2-piperidin-4-yloxy-5-(trifluoromethyl)pyridine2-piperidin-4-yloxy-5-(trifluoromethyl)pyridine
5
10
1,2-ETHANEDIOL1,2-ETHANEDIOL
6
4
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303