5WZX: Structural basis for a pentacyclic oleanane-type triterpenoid as a ligand of FXR

PDB ID: 5WZXDownload
MMDB ID: 157925
PDB Deposition Date: 2017/1/19
Updated in MMDB: 2018/12
Experimental Method:
x-ray diffraction
Resolution: 2.95  Å
Source Organism:
Similar Structures:
Biological Unit for 5WZX: dimeric; determined by author and by software (PISA)
Molecular Components in 5WZX
Label Count Molecule
Proteins (2 molecules)
1
Bile Acid Receptor
(Gene symbol: NR1H4)
Molecule annotation
1
Src2-3 Peptide From Nuclear Receptor Coactivator 2
(Gene symbol: NCOA2)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
(4aR,6aR,6aS,6bS,8aS,9R,12aR,14bR)-2,2,6a,6b,9,12a-hexamethyl-10-oxidanylidene-1,3,4,5,6,6a,7,8,8a,9,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid(4aR,6aR,6aS,6bS,8aS,9R,12aR,14bR)-2,2,6a,6b,9,12a-hexamethyl-10-oxidanylidene-1,3,4,5,6,6a,7,8,8a,9,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
2
3
(R,R)-2,3-BUTANEDIOL(R,R)-2,3-BUTANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303