National Center for
Biotechnology Information

5XTI: Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2

PDB ID:

5XTI Download

MMDB ID:

171431

PDB Deposition Date:

2017/6/19

Updated in MMDB:

2021/03

Experimental Method:

electron microscopy

Resolution:

17.4 Å

Source Organism:

Bos taurus▼

Taxonomy

Molecule

Bos taurus

x, y, z, 0, 1, 2, 3, 4, 5, 6, 7, 8,
9, Bx, By, Bz, B0, B1, B2, B3, B
4, B5, B6, B7, B8, B9

Homo sapiens

A, B, C, E, F, G, H, I, J, K, L, M,
N, O, P, Q, S, T, U, V, W, X, Y,
Z, a, b, c, d, e, f, g, h, i, j
, k, l, m, n, o, p, r, s, u, v,
w, AA, AB, AC, AD, AE, AF, AG, A
H, AJ, AK, AL, AN, AO, AP, AQ, A
R, AS, AT, AU, AV, AW, AY, BA, B
B, BC, BE, BF, BG, BH, BI, BJ, B
K, BL, BM, BN, BO, BP, BQ, BS, B
T, BU, BV, BW, BX, BY, BZ, Ba, B
b, Bc, Bd, Be, Bf, Bg, Bh, Bi, B
j, Bk, Bl, Bm, Bn, Bo, Bp, Br, B
s, Bu, Bv, Bw

Similar Structures:

Biological Unit for 5XTI: 138-meric; determined by author

Molecular Components in 5XTI
Label	Count	Molecule
Proteins (138 molecules)
A BA	2	Nadh Dehydrogenase [ubiquinone] Flavoprotein 1, Mitochondrial
B BB	2	Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 8, Mitochondrial
C BC	2	Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 7, Mitochondrial
E BE	2	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 6
F BF	2	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 2
G X BG BX	4	Acyl Carrier Protein, Mitochondrial
H BH	2	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 5
I BI	2	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 7
J BJ	2	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 9, Mitochondrial
K BK	2	Nadh Dehydrogenase [ubiquinone] Flavoprotein 3, Mitochondrial
L BL	2	Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 4, Mitochondrial
M BM	2	Nadh-ubiquinone Oxidoreductase 75 KDA Subunit, Mitochondrial
N BN	2	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 12
O BO	2	Nadh Dehydrogenase [ubiquinone] Flavoprotein 2, Mitochondrial
P BP	2	Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 3, Mitochondrial
Q BQ	2	Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 2, Mitochondrial
S BS	2	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 1
T BT	2	Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 6, Mitochondrial
U BU	2	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 3
V BV	2	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 11
W BW	2	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 13
Y BY	2	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 2, Mitochondrial
Z BZ	2	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 3
a Ba	2	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 5, Mitochondrial
b Bb	2	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 6
c Bc	2	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 8, Mitochondrial
d Bd	2	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 10
e Be	2	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 11, Mitochondrial
f Bf	2	Nadh Dehydrogenase [ubiquinone] 1 Subunit C1, Mitochondrial
g Bg	2	Nadh Dehydrogenase [ubiquinone] 1 Subunit C2
h Bh	2	Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 5
i Bi	2	Nadh-ubiquinone Oxidoreductase Chain 2
j Bj	2	Nadh-ubiquinone Oxidoreductase Chain 3
k Bk	2	Nadh-ubiquinone Oxidoreductase Chain 4L
l Bl	2	Nadh-ubiquinone Oxidoreductase Chain 5
m Bm	2	Nadh-ubiquinone Oxidoreductase Chain 6
n Bn	2	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 1
o Bo	2	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 4
p Bp	2	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 9
r Br	2	Nadh-ubiquinone Oxidoreductase Chain 4
s Bs	2	Nadh-ubiquinone Oxidoreductase Chain 1
u Bu	2	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 8
v Bv	2	Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 7
w Bw	2	Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 10, Mitochondrial
x Bx	2	Cytochrome C Oxidase Subunit 1
y By	2	Cytochrome C Oxidase Subunit 2
z Bz	2	Cytochrome C Oxidase Subunit 3
0 B0	2	Cytochrome C Oxidase Subunit 4 Isoform 1, Mitochondrial
1 B1	2	Cytochrome C Oxidase Subunit 5A, Mitochondrial
2 B2	2	Cytochrome C Oxidase Subunit 5B, Mitochondrial
3 B3	2	Cytochrome C Oxidase Subunit 6a2, Mitochondrial
4 B4	2	Cytochrome C Oxidase Subunit 6B1
5 B5	2	Cytochrome C Oxidase Subunit 6C
6 B6	2	Cytochrome C Oxidase Subunit 7a1, Mitochondrial
7 B7	2	Cytochrome C Oxidase Subunit 7B, Mitochondrial
8 B8	2	Cytochrome C Oxidase Subunit 7C, Mitochondrial
9 B9	2	Cytochrome C Oxidase Subunit 8B, Mitochondrial
AA AN	2	Cytochrome B-c1 Complex Subunit 8
AB AO	2	Cytochrome B-c1 Complex Subunit Rieske, Mitochondrial
AC AP	2	Cytochrome B-c1 Complex Subunit Rieske, Mitochondrial
AD AQ	2	Cytochrome B-c1 Complex Subunit 9
AE AR	2	Cytochrome B-c1 Complex Subunit 6, Mitochondrial
AF AS	2	Cytochrome B-c1 Complex Subunit 7
AG AT	2	Cytochrome B-c1 Complex Subunit 10
AH AU	2	Cytochrome C1, Heme Protein, Mitochondrial
AJ AV	2	Cytochrome B
AK AW	2	Cytochrome B-c1 Complex Subunit 2, Mitochondrial
AL AY	2	Cytochrome B-c1 Complex Subunit 1, Mitochondrial
Chemicals and Non-standard biopolymers (100 molecules)
1	12	IRON/SULFUR CLUSTER
2	2	FLAVIN MONONUCLEOTIDE
3	21	(9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL
4	4	S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate
5	2	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
6	6	FE2/S2 (INORGANIC) CLUSTER
7	19	CARDIOLIPIN
8	14	1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
9	6	COPPER (II) ION
10	2	MAGNESIUM ION
11	4	HEME-A
12	2	ZINC ION
13	2	HEME C
14	4	PROTOPORPHYRIN IX CONTAINING FE