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6CKC:
Structure of PRMT5:MEP50 in complex with LLY-283, a potent and selective inhibitor of PRMT5, with antitumor activity
PDB ID:
6CKC
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MMDB ID:
162120
PDB Deposition Date:
2018/2/27
Updated in MMDB:
2018/08
Experimental Method:
x-ray diffraction
Resolution:
2.8 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 6CKC: octameric; determined by author and by software (PISA)
Molecular Components in 6CKC
Label
Count
Molecule
Proteins (8 molecules)
A
A_1
A_2
A_3
4
Protein Arginine N-methyltransferase 5
(Gene symbol:
PRMT5
)
B
B_1
B_2
B_3
4
Methylosome Protein 50
(Gene symbol:
WDR77
)
Chemicals and Non-standard biopolymers (4 molecules)
1
4
7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303