6CQH: Crystal Structure of the Human vaccinia-related kinase bound to a N-propynyl-N-ethyl-dihydropteridine inhibitor

PDB ID: 6CQHDownload
MMDB ID: 160634
PDB Deposition Date: 2018/3/15
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.15  Å
Source Organism:
Similar Structures:
Biological Unit for 6CQH: monomeric; determined by author and by software (PISA)
Molecular Components in 6CQH
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase Vrk1
(Gene symbol: VRK1)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
(7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one(7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one
2
2
SULFATE IONSULFATE ION
3
1
ACETATE IONACETATE ION
4
1
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303