6CWY: Crystal structure of SUMO E1 in complex with an allosteric inhibitor

PDB ID: 6CWYDownload
MMDB ID: 170456
PDB Deposition Date: 2018/4/1
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.462  Å
Source Organism:
Similar Structures:
Biological Unit for 6CWY: dimeric; determined by author and by software (PISA)
Molecular Components in 6CWY
Label Count Molecule
Proteins (2 molecules)
1
Sumo-activating Enzyme Subunit 1
(Gene symbol: SAE1)
Molecule annotation
1
Sumo-activating Enzyme Subunit 2
(Gene symbol: UBA2)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
2
GLYCEROLGLYCEROL
2
1
ZINC IONZINC ION
3
1
MAGNESIUM IONMAGNESIUM ION
4
4
SULFATE IONSULFATE ION
5
1
dimethyl (1S,2S,3R,4R)-1-[(1S)-2-(4-methylphenyl)-1-(phenylamino)ethyl]-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylatedimethyl (1S,2S,3R,4R)-1-[(1S)-2-(4-methylphenyl)-1-(phenylamino)ethyl]-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303