6FF7: human Bact spliceosome core structure

PDB ID: 6FF7Download
MMDB ID: 173060
PDB Deposition Date: 2018/1/3
Updated in MMDB: 2019/12
Experimental Method:
electron microscopy
Resolution: 4.5  Å
Source Organism:
Similar Structures:
Biological Unit for 6FF7: 61-meric; determined by author
Molecular Components in 6FF7
Label Count Molecule
Proteins (57 molecules)
1
RNA-binding Motif Protein, X-linked 2
(Gene symbol: RBMX2)
Molecule annotation
1
Bud13 Homolog
(Gene symbol: BUD13)
Molecule annotation
1
Splicing Factor 3A Subunit 2
(Gene symbol: SF3A2)
Molecule annotation
1
Splicing Factor 3B Subunit 2
(Gene symbol: SF3B2)
Molecule annotation
1
Pre-mrna-processing-splicing Factor 8
(Gene symbol: PRPF8)
Molecule annotation
1
116 KDA U5 Small Nuclear Ribonucleoprotein Component
(Gene symbol: EFTUD2)
Molecule annotation
1
SNW Domain-containing Protein 1
(Gene symbol: SNW1)
Molecule annotation
1
Pleiotropic Regulator 1
(Gene symbol: PLRG1)
Molecule annotation
1
Pre-mrna-processing Factor 17
(Gene symbol: CDC40)
Molecule annotation
1
Cell Division Cycle 5-like Protein
(Gene symbol: CDC5L)
Molecule annotation
1
Crooked Neck-like Protein 1
(Gene symbol: CRNKL1)
Molecule annotation
1
Pre-mrna-splicing Factor Rbm22
(Gene symbol: RBM22)
Molecule annotation
1
Protein Bud31 Homolog
(Gene symbol: BUD31)
Molecule annotation
1
Spliceosome-associated Protein Cwc15 Homolog
(Gene symbol: CWC15)
Molecule annotation
1
Serine/arginine Repetitive Matrix Protein 2
(Gene symbol: SRRM2)
Molecule annotation
1
Peptidyl-prolyl Cis-trans Isomerase-like 1
(Gene symbol: PPIL1)
Molecule annotation
1
Serine/arginine Repetitive Matrix Protein 1
(Gene symbol: SRRM1)
Molecule annotation
1
Peptidyl-prolyl Cis-trans Isomerase Cwc27 Homolog
(Gene symbol: CWC27)
Molecule annotation
1
Ring Finger Protein 113a
(Gene symbol: RNF113A)
Molecule annotation
1
Splicing Factor 3B Subunit 1
(Gene symbol: SF3B1)
Molecule annotation
1
Splicing Factor 3B Subunit 3
(Gene symbol: SF3B3)
Molecule annotation
1
Splicing Factor 3B Subunit 5
(Gene symbol: SF3B5)
Molecule annotation
1
PHD Finger-like Domain-containing Protein 5A
(Gene symbol: PHF5A)
Molecule annotation
2
Splicing Factor 3B Subunit 6
(Gene symbol: SF3B6)
Molecule annotation
1
Smad Nuclear-interacting Protein 1
(Gene symbol: SNIP1)
Molecule annotation
1
Splicing Factor 3A Subunit 3
(Gene symbol: SF3A3)
Molecule annotation
1
U5 Small Nuclear Ribonucleoprotein 40 KDA Protein
(Gene symbol: SNRNP40)
Molecule annotation
4
Pre-mrna-processing Factor 19
(Gene symbol: PRPF19)
Molecule annotation
1
Pre-mrna-splicing Factor Spf27
(Gene symbol: BCAS2)
Molecule annotation
1
Pre-mrna-splicing Factor Syf1
(Gene symbol: XAB2)
Molecule annotation
1
Pre-mrna-splicing Factor Cwc22 Homolog
(Gene symbol: CWC22)
Molecule annotation
1
Intron-binding Protein Aquarius
(Gene symbol: AQR)
Molecule annotation
1
U2 Small Nuclear Ribonucleoprotein A'
(Gene symbol: SNRPA1)
Molecule annotation
1
U2 Small Nuclear Ribonucleoprotein B''
(Gene symbol: SNRPB2)
Molecule annotation
2
Small Nuclear Ribonucleoprotein SM D2
(Gene symbol: SNRPD2)
Molecule annotation
2
Small Nuclear Ribonucleoprotein F
(Gene symbol: SNRPF)
Molecule annotation
2
Small Nuclear Ribonucleoprotein E
(Gene symbol: SNRPE)
Molecule annotation
2
Small Nuclear Ribonucleoprotein G
(Gene symbol: SNRPG)
Molecule annotation
2
Small Nuclear Ribonucleoprotein SM D3
(Gene symbol: SNRPD3)
Molecule annotation
2
Small Nuclear Ribonucleoprotein-associated Proteins B and B'
(Gene symbol: SNRPB)
Molecule annotation
2
Small Nuclear Ribonucleoprotein SM D1
(Gene symbol: SNRPD1)
Molecule annotation
1
Peptidyl-prolyl Cis-trans Isomerase E
(Gene symbol: PPIE)
Molecule annotation
1
Splicing Factor 3A Subunit 1
(Gene symbol: SF3A1)
Molecule annotation
1
Putative Pre-mrna-splicing Factor Atp-dependent RNA Helicase Dhx16
(Gene symbol: DHX16)
Molecule annotation
1
U5 Small Nuclear Ribonucleoprotein 200 KDA Helicase
(Gene symbol: SNRNP200)
Molecule annotation
1
Pre-mrna-splicing Factor Isy1 Homolog
(Gene symbol: ISY1)
Molecule annotation
Nucleotides(4 molecules)
1
U2 Snrna
Molecule annotation
1
U5 Snrna
Molecule annotation
1
U6 Snrna
Molecule annotation
1
Pre-mrna
Molecule annotation
Chemicals and Non-standard biopolymers (20 molecules)
1
11
ZINC IONZINC ION
2
5
MAGNESIUM IONMAGNESIUM ION
3
1
INOSITOL HEXAKISPHOSPHATEINOSITOL HEXAKISPHOSPHATE
4
1
GUANOSINE-5'-TRIPHOSPHATEGUANOSINE-5'-TRIPHOSPHATE
5
2
ADENOSINE-5'-DIPHOSPHATEADENOSINE-5'-DIPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303