6IBR: Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclophellitol epoxide LWA481

PDB ID: 6IBRDownload
MMDB ID: 180249
PDB Deposition Date: 2018/11/30
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.02  Å
Source Organism:
Similar Structures:
Biological Unit for 6IBR: dimeric; determined by software (PISA)
Molecular Components in 6IBR
Label Count Molecule
Proteins (2 molecules)
2
Alpha-galactosidase a
(Gene symbol: GLA)
Molecule annotation
Chemicals and Non-standard biopolymers (43 molecules)
1
11
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
3
beta-D-mannopyranosebeta-D-mannopyranose
3
1
alpha-D-mannopyranosealpha-D-mannopyranose
4
7
SULFATE IONSULFATE ION
5
9
1,2-ETHANEDIOL1,2-ETHANEDIOL
6
4
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
7
6
ACETATE IONACETATE ION
8
2
(2~{R},3~{S},4~{S},5~{R},6~{S})-5-(hydroxymethyl)-7-oxabicyclo[4.1.0]heptane-2,3,4-triol(2~{R},3~{S},4~{S},5~{R},6~{S})-5-(hydroxymethyl)-7-oxabicyclo[4.1.0]heptane-2,3,4-triol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303