6RX2: Fragment AZ-005 binding at the p53pT387/14-3-3 sigma interface

PDB ID: 6RX2Download
MMDB ID: 188992
PDB Deposition Date: 2019/6/7
Updated in MMDB: 2020/07
Experimental Method:
x-ray diffraction
Resolution: 1.82  Å
Source Organism:
Similar Structures:
Biological Unit for 6RX2: tetrameric; determined by author and by software (PISA)
Molecular Components in 6RX2
Label Count Molecule
Proteins (4 molecules)
2
14-3-3 Protein Sigma
(Gene symbol: SFN)
Molecule annotation
2
Cellular Tumor Antigen P53
(Gene symbol: TP53)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
6
MAGNESIUM IONMAGNESIUM ION
2
2
CALCIUM IONCALCIUM ION
3
2
7-[[(2~{S})-1-azanylpropan-2-yl]amino]-1-benzothiophene-2-carboximidamide7-[[(2~{S})-1-azanylpropan-2-yl]amino]-1-benzothiophene-2-carboximidamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303