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6UO8:
Human metabotropic GABA(B) receptor bound to agonist SKF97541 and positive allosteric modulator GS39783
PDB ID:
6UO8
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MMDB ID:
188761
PDB Deposition Date:
2019/10/14
Updated in MMDB:
2020/08
Experimental Method:
electron microscopy
Resolution:
3.63 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
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Biological Unit for 6UO8: dimeric; determined by author
Molecular Components in 6UO8
Label
Count
Molecule
Proteins (2 molecules)
A
1
Gamma-aminobutyric Acid Type B Receptor Subunit 1
(Gene symbol:
GABBR1
)
B
1
Gamma-aminobutyric Acid Type B Receptor Subunit 2
(Gene symbol:
GABBR2
)
Chemicals and Non-standard biopolymers (15 molecules)
1
12
2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
beta-D-mannopyranose
3
1
(R)-(3-aminopropyl)methylphosphinic acid
4
1
N~4~,N~6~-dicyclopentyl-2-(methylsulfanyl)-5-nitropyrimidine-4,6-diamine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303