6V9U: Crystal structure of human TLR8 ectodomain bound to small molecule antagonist 14c

PDB ID: 6V9UDownload
MMDB ID: 191153
PDB Deposition Date: 2019/12/16
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.65  Å
Source Organism:
Similar Structures:
Biological Unit for 6V9U: dimeric; determined by author and by software (PISA)
Molecular Components in 6V9U
Label Count Molecule
Proteins (2 molecules)
2
Toll-like Receptor 8
(Gene symbol: TLR8)
Molecule annotation
Chemicals and Non-standard biopolymers (44 molecules)
1
29
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
5
beta-D-mannopyranosebeta-D-mannopyranose
3
8
alpha-D-mannopyranosealpha-D-mannopyranose
4
2
2-(3,4-dimethoxyphenyl)-5-(piperidin-4-yl)-3-(propan-2-yl)-1H-indole2-(3,4-dimethoxyphenyl)-5-(piperidin-4-yl)-3-(propan-2-yl)-1H-indole
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303