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6YQO:
Crystal structure of the first bromodomain of human BRD4 in complex with the dual inhibitor TW12
PDB ID:
6YQO
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MMDB ID:
187347
PDB Deposition Date:
2020/4/17
Updated in MMDB:
2020/05
Experimental Method:
x-ray diffraction
Resolution:
1.07 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 6YQO: monomeric; determined by author and by software (PISA)
Molecular Components in 6YQO
Label
Count
Molecule
Protein (1 molecule)
A
1
Bromodomain-containing Protein 4
(Gene symbol:
BRD4
)
Chemicals and Non-standard biopolymers (4 molecules)
1
3
1,2-ETHANEDIOL
2
1
(S)-N1-(4-(2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)phenyl)-N8-hydroxyoctanediamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303