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7LBM: Structure of the human Mediator-bound transcription pre-initiation complex

PDB ID:	7LBM Download
MMDB ID:	200198
PDB Deposition Date:	2021/1/8
Updated in MMDB:	2024/10
Experimental Method:	electron microscopy
Resolution:	4.8 Å
Source Organism:	Homo sapiens
Similar Structures:

Biological Unit for 7LBM: 56-meric; determined by author

Molecular Components in 7LBM
Label	Count	Molecule
Proteins (54 molecules)
0	1	Isoform 2 of Mediator of RNA Polymerase II Transcription Subunit 16
1	1	Mediator of RNA Polymerase II Transcription Subunit 23
2	1	Mediator of RNA Polymerase II Transcription Subunit 24
3	1	Mediator of RNA Polymerase II Transcription Subunit 25
A	1	DNA-directed RNA Polymerase II Subunit Rpb1
B	1	DNA-directed RNA Polymerase II Subunit Rpb2
C	1	DNA-directed RNA Polymerase II Subunit Rpb3
D	1	DNA-directed RNA Polymerase II Subunit Rpb4
E	1	DNA-directed RNA Polymerase II Subunit Rpb5
F	1	DNA-directed RNA Polymerases I, II, and III Subunit Rpabc2
G	1	DNA-directed RNA Polymerase II Subunit Rpb7
H	1	DNA-directed RNA Polymerases I, II, and III Subunit Rpabc3
I	1	DNA-directed RNA Polymerase II Subunit Rpb9
J	1	DNA-directed RNA Polymerases I, II, and III Subunit Rpabc5
K	1	DNA-directed RNA Polymerase II Subunit Rpb11-a
L	1	DNA-directed RNA Polymerases I, II, and III Subunit Rpabc4
M	1	Transcription Initiation Factor IIA Subunit 1 (Gene symbol: GTF2A1)
N	1	Transcription Initiation Factor IIA Subunit 2 (Gene symbol: GTF2A2)
O	1	Transcription Initiation Factor IIB (Gene symbol: GTF2B)
P	1	Tata-box-binding Protein (Gene symbol: TBP)
Q	1	General Transcription Factor IIE Subunit 1 (Gene symbol: GTF2E1)
R	1	Transcription Initiation Factor IIE Subunit Beta (Gene symbol: GTF2E2)
S	1	General Transcription Factor IIF Subunit 1 (Gene symbol: GTF2F1)
T	1	General Transcription Factor IIF Subunit 2 (Gene symbol: GTF2F2)
W	1	Tfiih Basal Transcription Factor Complex Helicase XPB Subunit
X	1	Tfiih Basal Transcription Factor Complex Helicase XPD Subunit
Y	1	General Transcription Factor IIH Subunit 1
Z	1	General Transcription Factor IIH Subunit 4, P52
a	1	General Transcription Factor IIH Subunit 2
b	1	General Transcription Factor IIH Subunit 3
c	1	General Transcription Factor IIH Subunit 5
d	1	Cdk-activating Kinase Assembly Factor Mat1
e	1	Cyclin-dependent Kinase 7
f	1	Cyclin-h
g	1	Mediator of RNA Polymerase II Transcription Subunit 6
h	1	Mediator of RNA Polymerase II Transcription Subunit 8
i	1	Mediator of RNA Polymerase II Transcription Subunit 11
j	1	Mediator of RNA Polymerase II Transcription Subunit 17
k	1	Mediator of RNA Polymerase II Transcription Subunit 18
l	1	Mediator of RNA Polymerase II Transcription Subunit 20
m	1	Mediator of RNA Polymerase II Transcription Subunit 22
n	1	Mediator of RNA Polymerase II Transcription Subunit 27
o	1	Mediator of RNA Polymerase II Transcription Subunit 28
p	1	Mediator of RNA Polymerase II Transcription Subunit 29
q	1	Mediator of RNA Polymerase II Transcription Subunit 30
r	1	Mediator of RNA Polymerase II Transcription Subunit 14
s	1	Mediator of RNA Polymerase II Transcription Subunit 4
t	1	Mediator of RNA Polymerase II Transcription Subunit 7
u	1	Mediator of RNA Polymerase II Transcription Subunit 9
v	1	Mediator of RNA Polymerase II Transcription Subunit 10
w	1	Mediator of RNA Polymerase II Transcription Subunit 19
x	1	Mediator of RNA Polymerase II Transcription Subunit 21
y	1	Mediator of RNA Polymerase II Transcription Subunit 31
z	1	Mediator of RNA Polymerase II Transcription Subunit 15
Nucleotides(2 molecules)
U	1	Super Core Promoter Sense Strand
V	1	Super Core Promoter Antisense Strand
Chemicals and Non-standard biopolymers (19 molecules)
1	2	MAGNESIUM ION
2	16	ZINC ION
3	1	IRON/SULFUR CLUSTER

* Click molecule labels to explore molecular sequence information.

Citing MMDB

Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303