7MXA: PRMT5:MEP50 complexed with inhibitor PF-06855800

PDB ID: 7MXADownload
MMDB ID: 208936
PDB Deposition Date: 2021/5/18
Updated in MMDB: 2021/11
Experimental Method:
x-ray diffraction
Resolution: 2.713  Å
Source Organism:
Similar Structures:
Biological Unit for 7MXA: octameric; determined by author and by software (PISA)
Molecular Components in 7MXA
Label Count Molecule
Proteins (8 molecules)
4
Protein Arginine N-methyltransferase 5
(Gene symbol: PRMT5)
Molecule annotation
4
Methylosome Protein 50
(Gene symbol: WDR77)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
4
7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303