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8IUE: RNA polymerase III pre-initiation complex melting complex 1

PDB ID:	8IUE Download
MMDB ID:	230636
PDB Deposition Date:	2023/3/24
Updated in MMDB:	2024/07
Experimental Method:	electron microscopy
Resolution:	4.1 Å
Source Organism:	Homo sapiens
Similar Structures:

Biological Unit for 8IUE: 25-meric; determined by author

Molecular Components in 8IUE
Label	Count	Molecule
Proteins (23 molecules)
A	1	DNA-directed RNA Polymerase III Subunit Rpc1 (Gene symbol: POLR3A)
B	1	DNA-directed RNA Polymerase III Subunit Rpc2 (Gene symbol: POLR3B)
C	1	DNA-directed RNA Polymerases I and III Subunit Rpac1 (Gene symbol: POLR1C)
D	1	DNA-directed RNA Polymerase III Subunit Rpc9 (Gene symbol: CRCP)
E	1	DNA-directed RNA Polymerases I, II, and III Subunit Rpabc1 (Gene symbol: POLR2E)
F	1	DNA-directed RNA Polymerases I, II, and III Subunit Rpabc2 (Gene symbol: POLR2F)
G	1	DNA-directed RNA Polymerase III Subunit Rpc8 (Gene symbol: POLR3H)
H	1	DNA-directed RNA Polymerases I, II, and III Subunit Rpabc3 (Gene symbol: POLR2H)
I	1	DNA-directed RNA Polymerase III Subunit Rpc10 (Gene symbol: POLR3K)
J	1	DNA-directed RNA Polymerases I, II, and III Subunit Rpabc5 (Gene symbol: POLR2L)
K	1	DNA-directed RNA Polymerases I and III Subunit Rpac2 (Gene symbol: POLR1D)
L	1	DNA-directed RNA Polymerases I, II, and III Subunit Rpabc4 (Gene symbol: POLR2K)
M	1	DNA-directed RNA Polymerase III Subunit Rpc5 (Gene symbol: POLR3E)
N	1	DNA-directed RNA Polymerase III Subunit Rpc4 (Gene symbol: POLR3D)
O	1	DNA-directed RNA Polymerase III Subunit Rpc3 (Gene symbol: POLR3C)
P	1	DNA-directed RNA Polymerase III Subunit Rpc6 (Gene symbol: POLR3F)
Q	1	DNA-directed RNA Polymerase III Subunit Rpc7 (Gene symbol: POLR3G)
1	1	Snrna-activating Protein Complex Subunit 1 (Gene symbol: SNAPC1)
3	1	Snrna-activating Protein Complex Subunit 3 (Gene symbol: SNAPC3)
4	1	Snrna-activating Protein Complex Subunit 4 (Gene symbol: SNAPC4)
U	1	Tata-box-binding Protein (Gene symbol: TBP)
V	1	Transcription Factor Iiib 50 KDA Subunit (Gene symbol: BRF2)
W	1	Transcription Factor Tfiiib Component B'' Homolog (Gene symbol: BDP1)
Nucleotides(2 molecules)
X	1	Human Gene for U 6 RNA
Y	1	DNA (74-mer)
Chemicals and Non-standard biopolymers (10 molecules)
1	8	ZINC ION
2	1	MAGNESIUM ION
3	1	IRON/SULFUR CLUSTER

* Click molecule labels to explore molecular sequence information.

Citing MMDB

Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303