8T6F: Crystal structure of human MBP-Myeloid cell leukemia 1 (Mcl-1) in complex with BRD810 inhibitor

PDB ID: 8T6FDownload
MMDB ID: 248562
PDB Deposition Date: 2023/6/15
Updated in MMDB: 2024/09
Experimental Method:
x-ray diffraction
Resolution: 1.56  Å
Source Organism:
Similar Structures:
Biological Unit for 8T6F: monomeric; determined by author and by software (PISA)
Molecular Components in 8T6F
Label Count Molecule
Protein (1 molecule)
1
Maltose/maltodextrin-binding Periplasmic Protein/induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Chimera
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
alpha-D-glucopyranosealpha-D-glucopyranose
2
1
MAGNESIUM IONMAGNESIUM ION
3
1
(3aM,9S,15R)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4',3':9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid(3aM,9S,15R)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4',3':9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid
4
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
5
1
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303