Figure 11. Modeling of CID-2431573 in F6P binding site of Tb PFK.
Figure 11. Modeling of CID-2431573 in F6P binding site of Tb PFK.
Figure 11. Modeling of CID-2431573 in F6P binding site of Tb PFK.

Figure 11Modeling of CID-2431573 in F6P binding site of Tb PFK

A. Rendering of the tunnel-like active site of Tb PFK and docking of CID-2431573 (pink) in the F6P binding site (ATP is shown in gold); B. Alternative view showing hydrophobic pocket that is predicted to be occupied by the dichlorobenzyl functionality of CID-2431573 (pink); C. Interior of Tb PFK active site and predicted interaction with CID-2431573 (cyan).

From: Identification of Selective Inhibitors of Phosphofructokinase as Lead Compounds Against Trypanosomiasis

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