| Orlistat | Gastric Lipase inhibitor-inhibits fat absorption | Less | 1. Reduced gallbladder function
3. Use with caution with pancreatic or liver disease | Some patients may develop increased levels of urinary oxalate and kidney stones | 1.steatorrhea
2. diarrhea
3. flatulence
4. increased stooling
|
| Phentermine | Central appetite suppressant, sympathomimetic amine | Better
Intended as short term agent (< 6 mos), | 1. History of cardiovascular disease
2. During or within 2 weeks following the administration of monoamine oxidase inhibitors
3. Hyperthyroidism.
4. Glaucoma.
5. Agitated states.
6. History of drug abuse | 1. May impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or driving a motor vehicle
2. Abuse or addiction | 1.feeling restless; 2.headache, 3.dizziness, 4. tremors; 5.poor sleep,
6. dry mouth |
| Lorcarserin | Central appetite suppressant, aserotonin 2C receptor agonist | Less | caution if
1. renal failure
2. CHF, bradycardia or heart block
3. diabetes mellitus
4, priapism
or penile deformities
5. depression | 1. valvular heart disease (symptoms: shortness of breath, edemas)
2. mental illness (depression, suicidal mood)
3. serotonin neuroleptic malignant syndrome (symptoms: excitement, nausea, sweating, tachycardia) | 1.hypoglycemia
2. mental issues
3. bradycardia
4.headache
5. dizziness
6.drowsiness
7.fatigue,
8. nausea
9.dry mouth
10.constipation
11. painful erections |
| Liraglutide | Central appetite suppressant, long-acting glucagon-like peptide-1 receptor agonist | Better | 1. Personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
2. Avoid in patients with history or pancreatitis
Caution
1. May | 1. Possible thyroid tumors including cancer
2. Pancreatitis | 1. nausea/ vomiting
2.hypoglycemia
3. diarrhea
4.constipation
5.headache
6. fatigue
7. dizziness
8. increased lipase |
| Phentermine/ Topiramate | Phentermine Central appetite suppressant, sympathomimetic amine
Topiramate is an anticonvulsant that has weight loss side effects | Best | 1. History of cardiovascular disease
2. During or within 2 weeks following the administration of monoamine oxidase inhibitors
3. Hyperthyroidism.
4. Glaucoma.
5. Agitated states.
6. History of drug abuse | 1. Suicidal behavior and ideation
2. Acute myopia and secondary angle glaucoma
3. Metabolic acidosis
4. Elevation in creatinine
5. CNS depression with concomitant CNS depressants including alcohol
6. Potential seizures with abrupt withdrawal of drug
7. Patients with renal impairment
8. Kidney stones
9. Oligohidrosis and hyperthermia
10.Hypokalemia | 1.mild dizziness 2.anxiety
3. fatigue or irritable
4. constipation
5. memory problems
6. poor sleep
7. numbness of tingly feeling
8. altered sense of taste
9.dry mouth |
| Naltrexone/ Buproprion | naltrexone, an opioid antagonist.
bupropion, a relatively weak inhibitor of the neuronal reuptake of dopamine and norepinephrine | Better | 1. History of seizures
2. History of an eating disorder
3. Taking opioid pain medicines, 4. Taking medicines to stop opioid addiction,
5. taking an MAOI within 2 weeks.
6.Abrupt termination of alcohol, benzodiazepines, barbiturates, or antiepileptic drugs | 1. Suicidal thoughts and behaviors
2. Neuropsychiatric reactions | 1.nausea
2.headache
3.vomiting
4.constipation
5.diarrhea
6.dizziness
7. Poor
8. dry mouth |
