Probe Reports from the NIH Molecular Libraries Program [Internet].
Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
%20for%20ML395%20in%20both%20A)%20a%20cellular%20assay%20(PMA-stimulated%20Calu-1%20cells%20and%20a%20basal%20HEK293-gfpPLD2%20stabkle%20cell%20line)%20with%20cellular%20PLD2%2C%20IC50%20%3D%20360%20nM%20and%20cellular%20PLD1%2C%20IC50%20%3E30%2C000%20nM%2C%20and%20B)%20a%20biochemical%20assay%20with%20purified%20PLD2%20(biochemical%20PLD2%2C%20IC50%20%3D%208%2C700%20nM)%20and%20PLD1%20(biochemical%20PLD1%2C%20IC50%20%3E30%2C000%20nM).&p=BOOKS&id=280050_ml395f6.jpg "Click on image to zoom")
Figure 4Concentration response curves (CRCs) for ML395 in both A) a cellular assay (PMA-stimulated Calu-1 cells and a basal HEK293-gfpPLD2 stabkle cell line) with cellular PLD2, IC50 = 360 nM and cellular PLD1, IC50 >30,000 nM, and B) a biochemical assay with purified PLD2 (biochemical PLD2, IC50 = 8,700 nM) and PLD1 (biochemical PLD1, IC50 >30,000 nM)