FIGURE 39.3.. Degradation of oligomannosyl N-glycans in the ER, cytoplasm, and lysosomes.

FIGURE 39.3.

Degradation of oligomannosyl N-glycans in the ER, cytoplasm, and lysosomes. Specific pathways exist for the degradation of free glycans released from misfolded glycoproteins and glycopeptides generated within the ER. Dolichol-linked oligosaccharides facing the cytoplasmic side of the ER can also be released by a pyrophosphatase and further degraded in lysosomes.

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From: Chapter 39, Glycans in Glycoprotein Quality Control

Cover of Essentials of Glycobiology
Essentials of Glycobiology [Internet]. 3rd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017.
Copyright 2015-2017 by The Consortium of Glycobiology Editors, La Jolla, California. All rights reserved.

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