Figure 13 displays a forest plot for the network meta-analysis of studies reporting ACR50 response rates. Twelve comparisons were used in this analysis. Study-level data used in this Figure are presented in Appendix C. This figure is described further in the KQ1 Results section “Biologic Head to Head: TNF Versus Non-TNF” as follows: “In the NWMA (Figure 13 for ACR50 and Figure 14 for radiographic joint damage), TNF therapy (monotherapy or with MTX) is compared with non-TNF therapy (monotherapy or with MTX). No comparisons were significant, except for a lower ACR50 response rate for ADA compared with TCZ (RR, 0.75; 95% CI, 0.58 to 0.95)”.

Figure 13Forest plot for network meta-analysis of ACR50 response rates: TNF biologic versus non-TNF biologic

95% CI = 95% confidence interval; ACR50 = American College of Rheumatology 50% improvement; MTX = methotrexate; RR = relative risk; TNF = tumor necrosis factor; vs. = versus.

From: Results

Cover of Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update
Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update [Internet].
Comparative Effectiveness Review, No. 211.
Donahue KE, Gartlehner G, Schulman ER, et al.
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