Figure 26 displays a forest plot for the network meta-analysis reporting all discontinuations in studies comparing TNF biologics plus MTX with csDMARDs. Eight comparisons were used in this analysis. Study-level data used in this Figure are presented in Appendix C. This figure is described further in the KQ3 Results section “TNF Biologic Versus csDMARD Monotherapy” as follows: “In NWMA, TNF biologics (ADA, CZP, ETN, IFX) plus MTX had lower overall discontinuations than the csDMARD SSZ (range of RR, 0.35 to 0.48 [95% CI, 0.18 to 0.89])”.

Figure 26Forest plot for network meta-analysis of all discontinuations: TNF + MTX versus csDMARD

95% CI = 95% confidence interval; MTX = methotrexate; RR = relative risk; TNF = tumor necrosis factor; vs. = versus.

From: Results

Cover of Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update
Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update [Internet].
Comparative Effectiveness Review, No. 211.
Donahue KE, Gartlehner G, Schulman ER, et al.
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