Figure 33 displays a forest plot for the network meta-analysis reporting discontinuations due to adverse events in studies comparing TNF biologics with TNF biologics. Six comparisons were used in this analysis. Study-level data used in this Figure are presented in Appendix C. This figure is described further in the KQ3 Results section “TNF vs. TNF” as follows: “IFX plus MTX led to higher rates of overall discontinuations due to adverse events than both CZP plus MTX (RR, 2.80; 95% CI, 1.24 to 6.31) and ETN plus MTX (RR, 3.76; 95% CI, 1.66 to 8.51). Other comparisons shown below did not have significant differences”.

Figure 33Forest plot for network meta-analysis of discontinuations due to adverse events: TNF versus TNF

95% CI = 95% confidence interval; MTX = methotrexate; RR = relative risk; TNF = tumor necrosis factor; vs. = versus.

From: Results

Cover of Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update
Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update [Internet].
Comparative Effectiveness Review, No. 211.
Donahue KE, Gartlehner G, Schulman ER, et al.
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