Figure 6 displays a forest plot for the network meta-analysis of studies reporting change from baseline in radiographic joint damage score. One comparison was used in this analysis. Study-level data used in this Figure are presented in Appendix C. This figure is described further in the KQ1 Results section “TNF Biologic: MTX Plus TNF Biologic vs. Monotherapy With Either MTX or TNF Biologic” as follows: “Results of the NWMA were consistent with the findings of the PREMIER study and favored the combination of MTX plus ADA versus ADA monotherapy for higher ACR50 response (relative risk [RR], 1.52; 95% confidence interval [CI], 1.28 to 1.80) and less radiographic progression (standardized mean difference [SMD], −0.38; 95% CI, −0.55 to 0.21)”.

Figure 6Forest plot for network meta-analysis of change from baseline in radiographic joint damage score: MTX plus TNF biologic versus TNF biologic

95% CI = 95% confidence interval; MTX = methotrexate; SMD = standardized mean difference (mean difference divided by standard deviation); TNF = tumor necrosis factor; vs. = versus.

From: Results

Cover of Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update
Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update [Internet].
Comparative Effectiveness Review, No. 211.
Donahue KE, Gartlehner G, Schulman ER, et al.
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