Figure 23 is titled “Standardized mean change from baseline in depressive severity for selective serotonin reuptake inhibitors compared with placebo.” The figure displays a forest plot reporting the standardized mean difference in depression symptoms stratified by citalopram compared with placebo, fluoxetine compared with placebo, paroxetine compared with placebo, and sertraline compared with placebo. This figure is described further in the “Prevention or Reduction of Comorbid Medical or Psychiatric Conditions” section as follows: “One small trial provided insufficient evidence to determine efficacy of citalopram for reducing comorbid depression in adults with PTSD. The three fluoxetine trials had mixed results with limited evidence of no benefit (low SOE); one trial evidenced significant benefit of fluoxetine, another trial that tested two different doses of fluoxetine favored both drug arms but not significantly so, and the third trial found the placebo group to have non-significantly greater decreases in depression than fluoxetine participants (p=ns). Both paroxetine trials found significantly greater decreases among intervention group versus placebo group subjects in depression symptoms (moderate SOE). Decreases in depression symptoms at end-of-treatment did not differ between sertraline and placebo groups (SMD, −0.14; 95% CI, −0.33 to 0.06, 7 trials, N=1,085; low for no difference).”

Figure 23Standardized mean change from baseline in depressive symptoms for selective serotonin reuptake inhibitors compared with placebo

CI = confidence interval; SMD = standardized mean difference; SSRI = selective serotonin reuptake inhibitor.

From: Results

Cover of Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update
Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update [Internet].
Comparative Effectiveness Review, No. 207.
Forman-Hoffman V, Middleton JC, Feltner C, et al.
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