Figure 2. Algorithm for HBV Screening and Vaccination in Patients With HIV.

Figure 2Algorithm for HBV Screening and Vaccination in Patients With HIV

Abbreviations: anti-HBc, hepatitis B core antibody; anti-HBs, hepatitis B surface antibody; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus.

Notes:

a

In patients with positive anti-HBc, negative anti-HBs, and negative HBsAg test results, vaccinate with 1 standard dose of HBV vaccine and check anti-HBs titer after 8 weeks. If titer is <100 mlU/mL, complete remaining doses in the vaccine series and recheck titer 8 weeks after the last vaccine.

b

In patients with anti-HBs levels <10 mlU/mL (vaccine nonresponse), revaccination is recommended with the Heplisav-B vaccine series or a double dose of the vaccine series previously administered.

c

A patient who is negative for all serologies and who does not respond to revaccination may have a primary nonresponse or chronic infection. HBV DNA testing may be used to detect the presence of chronic HBV infection.

From: Prevention and Management of Hepatitis B Virus Infection in Adults With HIV

Cover of Prevention and Management of Hepatitis B Virus Infection in Adults With HIV
Prevention and Management of Hepatitis B Virus Infection in Adults With HIV [Internet].
Gupta A, Fine SM, Vail RM, et al.
Baltimore (MD): Johns Hopkins University; 2022 Aug.
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