Figure 9. Five analogues selected for submission to support probe ML205, SID 99437306, CID 46931017 and associated data.

Figure 9Five analogues selected for submission to support probe ML205, SID 99437306, CID 46931017 and associated data

EntrySIDCIDTbHK1 IC50 μMG6PDH IC50 μMIMR90 EC50 μMhGIk % inhibition at 10 μMBSF % inhibition at 10 μM
199380773469161683.46> 25> 2528.429 ± 6
299222690454361312.89> 25> 25034 ± 10
399380766469161654.59> 25> 2522.343 ± 12
499460893469478751.36> 25> 25035 ± 11
5103023816497666192.79> 25> 25032 ± 11

From: Identification of Inhibitors of Trypanosoma brucei Hexokinases

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