Figure 5. A) Activity coefficients increase nonlinearly with cellular concentrations of macromolecules.

Figure 5

A) Activity coefficients increase nonlinearly with cellular concentrations of macromolecules. The log of the activity coefficient of hemoglobin is plotted against the concentration of hemoglobin. Reprinted from reference 19. B) The effect of crowding on activity is exerted by large molecules on large molecules. The change in activity coefficient of a test molecule introduced into a solution of hemoglobin as crowding agent was measured with respect to the molecular weight of the test molecule. Reprinted with author permission from reference 20.

From: Protein Misassembly: Macromolecular Crowding and Molecular Chaperones

Cover of Madame Curie Bioscience Database
Madame Curie Bioscience Database [Internet].
Austin (TX): Landes Bioscience; 2000-2013.
Copyright © 2000-2013, Landes Bioscience.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.