| Search | Most Recent Queries | Result |
|---|---|---|
| #1 | Search “Antidepressive Agents”[MeSH] | 37171 |
| #2 | Search “Fluoxetine”[Mesh] OR “Sertraline”[Mesh] OR “Paroxetine”[Mesh] OR “Citalopram”[Mesh] OR “Fluvoxamine”[Mesh] OR “Bupropion”[Mesh] OR “nefazodone ”[Substance Name] OR “mirtazapine ”[Substance Name] OR “venlafaxine ”[Substance Name] OR “desmethylcitalopram ”[Substance Name] OR Escitalopram[tw] OR “duloxetine ”[Substance Name] OR “Trazodone”[Mesh] OR “O-desmethylvenlafaxine ”[Substance Name] OR “Imipramine”[Mesh] OR “Desipramine”[Mesh] OR “Nortriptyline”[Mesh] OR “Amitriptyline”[Mesh] OR “Phenelzine”[Mesh] OR “Tranylcypromine”[Mesh] OR “Doxepin”[Mesh] OR “Clomipramine”[Mesh] OR “Maprotiline”[Mesh] | 39294 |
| #3 | Search Fluoxetine OR Sertraline OR Paroxetine OR Citalopram OR Fluvoxamine OR Bupropion OR Nefazodone OR Mirtazapine OR Venlafaxine OR Escitalopram OR Duloxetine OR Trazodone OR Desvenlafaxine OR Imipramine OR Desipramine OR Nortriptyline OR Amitriptyline OR Phenelzine OR Tranylcypromine OR Doxepin OR Clomipramine OR Maprotiline | 48657 |
| #4 | Search #1 OR #2 OR #3 | 70932 |
| #5 | Search (“Depression”[MeSH] or “Depressive Disorder”[MeSH]) | 113094 |
| #6 | Search “Drug Resistance”[MeSH] OR refractory[tw] OR resistant[tw] | 387599 |
| #7 | Search #4 AND #5 AND #6 | 1359 |
| #8 | Search (“1980”[Entrez Date] : “3000”[Entrez Date]) AND (#7) Limits: Humans, English | 1075 |
| #9 | Search #8 Limits: Editorial, Letter, Case Reports | 222 |
| #10 | Search #8 Limits: All Infant: birth-23 months, All Child: 0-18 years, Newborn: birth-1 month, Infant: 1-23 months, Preschool Child: 2-5 years, Child: 6-12 years, Adolescent: 13-18 years | 105 |
| #11 | Search #8 NOT( #9 OR #10) Sort by: Title | 758 |
| Final number of records after duplicates removed (in comparison with the main TRD nonpharmacologic database). | 663 |
From: Appendix A, Search Strategy
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