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Jonas DE, Amick HR, Feltner C, et al. Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2014 May. (Comparative Effectiveness Reviews, No. 134.)

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Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings [Internet].

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Appendix BExcluded Studies

Exclusion Codes

  • X1: Not published in English
  • X2: Not original research
  • X3: Ineligible population
  • X4: Ineligible intervention
  • X5: Ineligible comparator
  • X6: Ineligible outcome
  • X7: Ineligible setting
  • X8: Ineligible study design
  • X9: Treatment duration less than 12 weeks
  • X10: Systematic review with search that ended prior to 2007
1.
Preventing Alcohol Withdrawal With Oral Baclofen. Exclusion Code: X7.
2.
Testing combined pharmacotherapies and behavioral interventions in alcohol dependence: Rationale and methods. Alcohol. 2003;27(7):1107–22. Exclusion Code: X6. [PubMed: 12878917]
3.
The Effects of Quetiapine (Seroquel XR) on Sleep During Alcohol Abstinence. 2013. Exclusion Code: X9.
4.
Oral vs. Injectable Naltrexone for Hospitalized Veterans With Alcohol Dependence. 2014. Exclusion Code: X7.
5.
Extended-Release vs. Oral Naltrexone Alcohol Treatment in Primary Care. 2018. Exclusion Code: X5.
6.
Harm Reduction With Pharmacotherapy (HaRP). 2018. Exclusion Code: X8.
7.
Abtahi MA, Abtahi SH, Fazel F, et al. Topiramate and the vision: A systematic review. Clin Opthalmol. 2012;6(1):117–31. Exclusion Code: X3. [PMC free article: PMC3261698] [PubMed: 22275816]
8.
Addolorato G, Caputo F, Capristo E, et al. Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled study. Alcohol Alcohol. 2002 Sep-Oct;37(5):504–8. Exclusion Code: X9. [PubMed: 12217947]
9.
Addolorato G, Leggio L, Ferrulli A, et al. Dose-response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trial. Alcohol Alcohol. 2011 May-Jun;46(3):312–7. Exclusion Code: X8. [PubMed: 21414953]
10.
Adler L, Wilens T, Zhang S, et al. Retrospective safety analysis of atomoxetine in adult ADHD patients with or without comorbid alcohol abuse and dependence. Am J Addict. 2009 Sep-Oct;18(5):393–401. Exclusion Code: X8. [PubMed: 19874159]
11.
Agosti V, Nunes EV, O'shea D. Do manualized psychosocial interventions help reduce relapse among alcohol-dependent adults treated with naltrexone or placebo? A meta-analysis. Am J Addict. 2012;21(6):501–7. Exclusion Code: X5. [PubMed: 23082827]
12.
Aguiar P, Neto D, Lambaz R, et al. Prognostic factors during outpatient treatment for alcohol dependence: Cohort study with 6 months of treatment follow-up. Alcohol Alcohol. 2012;47(6):702–10. Exclusion Code: X5. [PubMed: 22986010]
13.
Ait-Daoud N, Johnson BA, Javors M, et al. Combining ondansetron and naltrexone treats biological alcoholics: corroboration of self-reported drinking by serum carbohydrate deficient transferrin, a biomarker. Alcohol Clin Exp Res. 2001 Jun;25(6):847–9. Exclusion Code: X4. [PubMed: 11410720]
14.
Ait-Daoud N, Johnson BA, Prihoda TJ, et al. Combining ondansetron and naltrexone reduces craving among biologically predisposed alcoholics: preliminary clinical evidence. Psychopharmacology (Berl). 2001 Feb;154(1):23–7. Exclusion Code: X4. [PubMed: 11292002]
15.
Aliyev NN. Trial of interferon in chronic alcoholism. Psychiatry Res. 1994;54(3):307–8. Exclusion Code: X5. [PubMed: 7792335]
16.
Allen JP, Sillamaukee P, Anton R. Contribution of carbohydrate deficient transferrin to gamma glutamyl transpeptidase in evaluating progress of patients in treatment for alcoholism. Alcohol Clin Exp Res. 1999 Jan;23(1):115–20. Exclusion Code: X4. [PubMed: 10029211]
17.
Altamura AC, Mauri MC, Girardi T, et al. Alcoholism and depression: a placebo controlled study with viloxazine. Int J Clin Pharmacol Res. 1990;10(5):293–8. Exclusion Code: X6. [PubMed: 2079386]
18.
Altintoprak AE, Zorlu N, Coskunol H, et al. Effectiveness and tolerability of mirtazapine and amitriptyline in alcoholic patients with co-morbid depressive disorder: a randomized, double-blind study. Hum Psychopharmacol. 2008 Jun;23(4):313–9. Exclusion Code: X5. [PubMed: 18327889]
19.
Anderson N, Oliver MN. Oral topiramate effective for alcoholism. J Fam Pract. 2003;52(9):682–7. Exclusion Code: X2. [PubMed: 12967537]
20.
Angelone SM, Bellini L, Di Bella D, et al. Effects of fluvoxamine and citalopram in maintaining abstinence in a sample of Italian detoxified alcoholics. Alcohol Alcohol. 1998 Mar-Apr;33(2):151–6. Exclusion Code: X8. [PubMed: 9566477]
21.
Anton RF. Naltrexone for the management of alcohol dependence. N Engl J Med. 2008 Aug 14;359(7):715–21. Exclusion Code: X2. [PMC free article: PMC2565602] [PubMed: 18703474]
22.
Anton RF, Moak DH, Latham PK. The obsessive compulsive drinking scale: A new method of assessing outcome in alcoholism treatment studies. Arch Gen Psychiatry. 1996 Mar;53(3):225–31. Exclusion Code: X6. [PubMed: 8611059]
23.
Anton RF, Myrick H, Baros AM, et al. Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms. J Clin Psychopharmacol. 2009 Aug;29(4):334–42. Exclusion Code: X4. [PubMed: 19593171]
24.
Armeli S, Feinn R, Tennen H, et al. The effects of naltrexone on alcohol consumption and affect reactivity to daily interpersonal events among heavy drinkers. Exp Clin Psychopharmacol. 2006 May;14(2):199–208. Exclusion Code: X6. [PubMed: 16756424]
25.
Auriacombe M, Robinson M, Grabot D, et al. Naltrexone is ineffective to prevent relapse to alcohol in a realistic outpatient setting. A double blind one-year controlled study. College of Problems of Drug Dependence; San Juan, Puerto Rico: 2000. [abstract] Exclusion Code: X8.
26.
Back SE, Brady KT, Sonne SC, et al. Symptom improvement in co-occurring PTSD and alcohol dependence. J Nerv Ment Dis. 2006 Sep;194(9):690–6. Exclusion Code: X6. [PubMed: 16971821]
27.
Balldin J, Berggren U, Engel J, et al. Effect of citalopram on alcohol intake in heavy drinkers. Alcohol Clin Exp Res. 1994 Oct;18(5):1133–6. Exclusion Code: X3. [PubMed: 7847595]
28.
Baltieri DA, Correa Filho JM. Role of two clusters of male alcoholics in treatment retention. Eur Addict Res. 2012;18(4):201–11. Exclusion Code: X6. [PubMed: 22507891]
29.
Baltieri DA, de Andrade AG. Efficacy of acamprosate in the treatment of alcohol-dependent outpatients. Rev Bras Psiquiatr. 2003 Sep;25(3):156–9. Exclusion Code: X6. [PubMed: 12975689]
30.
Barber TJ, Marett B, Waldron S, et al. Are disulfiram-like reactions associated with abacavir-containing antiretroviral regimens in clinical practice? AIDS. 2007 Aug 20;21(13):1823–4. Exclusion Code: X8. [PubMed: 17690585]
31.
Baros AM, Latham PK, Anton RF. Naltrexone and cognitive behavioral therapy for the treatment of alcohol dependence: do sex differences exist? Alcohol Clin Exp Res. 2008 May;32(5):771–6. Exclusion Code: X8. [PMC free article: PMC2553698] [PubMed: 18336635]
32.
Baros AM, Latham PK, Moak DH, et al. What role does measuring medication compliance play in evaluating the efficacy of naltrexone? Alcohol Clin Exp Res. 2007 Apr;31(4):596–603. Exclusion Code: X6. [PubMed: 17374038]
33.
Barrias JA, Chabac S, Ferreira L, et al. Acamprosate: multicenter Portuguese efficacy and tolerance evaluation study. Psiquiatria Clinica. 1997;18:149–60. Exclusion Code: X1.
34.
Basu D, Jhirwal OP, Mattoo SK. Clinical characterization of use of acamprosate and naltrexone: data from an addiction center in India. Am J Addict. 2005 Jul-Sep;14(4):381–95. Exclusion Code: X8. [PubMed: 16188718]
35.
Beresford TP, Arciniegas D, Clapp L, et al. Reduction of affective lability and alcohol use following traumatic brain injury: a clinical pilot study of anti-convulsant medications. Brain Inj. 2005 Apr;19(4):309–13. Exclusion Code: X6. [PubMed: 15832875]
36.
Berglund KJ, Balldin J, Berggren U, et al. Childhood maltreatment affects the serotonergic system in male alcohol-dependent individuals. Alcohol. 2013;37(5):757–62. 2013-15234-008. First Author & Affiliation: Berglund, Kristina J. Exclusion Code: X8. [PubMed: 23384117]
37.
Bergstrom B, Ohlin H, Lindblom PE, et al. Is disulfiram implantation effective? Lancet. 1982 Jan 2;1(8262):49–50. Exclusion Code: X5. [PubMed: 6119442]
38.
Blomqvist O, Hernandez-Avila CA, Burleson JA, et al. Self-Efficacy as a Predictor of Relapse during Treatment for Alcohol Dependence. Addict Disord Their Treat. 2003;2(4):135–45. Exclusion Code: X8.
39.
Bonnet U, Specka M, Leweke FM, et al. Gabapentin's acute effect on mood profile -- a controlled study on patients with alcohol withdrawal. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):434–8. Exclusion Code: X3. [PubMed: 17178181]
40.
Brady KT, Sonne SC, Roberts JM. Sertraline treatment of comorbid posttraumatic stress disorder and alcohol dependence. J Clin Psychiatry. 1995 Nov;56(11):502–5. Exclusion Code: X5. [PubMed: 7592501]
41.
Brahen LS, Capone T, Heller RC, et al. Controlled clinical study of naltrexone side effects comparing first-day doses and maintenance regimens. Am J Drug Alcohol Abuse. 1978;5(2):235–45. CN-00019998. Exclusion Code: X3. [PubMed: 747177]
42.
Brahen LS, Henderson RK, Capone T, et al. Naltrexone treatment in a jail work-release program. J Clin Psychiatry. 1984;45(9, Sect 2):49–52. Exclusion Code: X3. [PubMed: 6469937]
43.
Brower KJ, Myra Kim H, Strobbe S, et al. A randomized double-blind pilot trial of gabapentin versus placebo to treat alcohol dependence and comorbid insomnia. Alcohol Clin Exp Res. 2008 Aug;32(8):1429–38. Exclusion Code: X9. [PMC free article: PMC2927959] [PubMed: 18540923]
44.
Brunette MF, O'Keefe C, Zimmet S, et al. Clozapine, olanzapine, or typical antipsychotics for alcohol use disorder in patients with schizophrenia. J Dual Diagn. 2008;4(4):344–54. Exclusion Code: X8.
45.
Bruno F. Buspirone in the treatment of alcoholic patients. Psychopathology. 1989;22 Suppl 1:49–59. Exclusion Code: X9. [PubMed: 2657838]
46.
Bujarski S, O'Malley SS, Lunny K, et al. The effects of drinking goal on treatment outcome for alcoholism. J Consult Clin Psychol. 2013;81(1):13–22. Exclusion Code: X6. [PMC free article: PMC4166539] [PubMed: 23231573]
47.
Buri C, Moggi F, Giovanoli A, et al. Prescription procedures in medication for relapse prevention after inpatient treatment for alcohol use disorders in Switzerland. Alcohol Alcohol. 2007 Jul-Aug;42(4):333–9. Exclusion Code: X8. [PubMed: 17517820]
48.
Burman WJ, Terra M, Breese P, et al. Lack of toxicity from concomitant directly observed disulfiram and isoniazid-containing therapy for active tuberculosis. Int J Tuberc Lung Dis. 2002;6(9):839–42. Exclusion Code: X8. [PubMed: 12234141]
49.
Capone C, Kahler CW, Swift RM, et al. Does family history of alcoholism moderate naltrexone's effects on alcohol use? J Stud Alcohol Drugs. 2011 Jan;72(1):135–40. Exclusion Code: X5. [PubMed: 21138720]
50.
Caputo F, Addolorato G, Lorenzini F, et al. Gamma-hydroxybutyric acid versus naltrexone in maintaining alcohol abstinence: an open randomized comparative study. Drug Alcohol Depend. 2003 May 1;70(1):85–91. Exclusion Code: X8. [PubMed: 12681528]
51.
Caputo F, Addolorato G, Stoppo M, et al. Comparing and combining gamma-hydroxybutyric acid (GHB) and naltrexone in maintaining abstinence from alcohol: an open randomised comparative study. Eur Neuropsychopharmacol. 2007 Dec;17(12):781–9. Exclusion Code: X5. [PubMed: 17611081]
52.
Carroll KM, Nich C, Ball SA, et al. Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram. Addiction. 1998 May;93(5):713–27. Exclusion Code: X5. [PubMed: 9692270]
53.
Carter AC, Miranda R, Gwaltney C, et al. Naltrexone's impact on alcohol expectancies in heavy drinkers. Alcoholism. 2010;34(6):177A. Exclusion Code: X3.
54.
Castro LA, Laranjeira R. [A double blind, randomized and placebo-controlled clinical trial with naltrexone and brief intervention in outpatient treatment of alcohol dependence]. J Bras Psiquiatr. 2009;58(2):79–85. CN-00754994. Exclusion Code: X1.
55.
Chen J, Johnson BA, Wang XQ, et al. Trajectory analyses in alcohol treatment research. Alcohol Clin Exp Res. 2012 Aug;36(8):1442–8. Exclusion Code: X6. [PMC free article: PMC3407320] [PubMed: 22525000]
56.
Chick J, Gough K, Falkowski W, et al. Disulfiram treatment of alcoholism. Br J Psychiatry. 1992 Jul;161:84–9. Exclusion Code: X8. [PubMed: 1638335]
57.
Christensen JK. Side-effects after Antabuse--myths or reality? Br J Clin Pract Suppl. 1984;36:21–8. Exclusion Code: X7. [PubMed: 6437426]
58.
Christensen JK, Ronsted P, Vaag UH. Side effects after disulfiram. Comparison of disulfiram and placebo in a double-blind multicentre study. Acta Psychiatr Scand. 1984 Apr;69(4):265–73. Exclusion Code: X9. [PubMed: 6372372]
59.
Ciraulo DA, Dong Q, Silverman BL, et al. Early treatment response in alcohol dependence with extended-release naltrexone. J Clin Psychiatry. 2008 Feb;69(2):190–5. Exclusion Code: X9. [PubMed: 18348601]
60.
Collins GB, Janesz JW, Byerly-Thrope J. The Cleveland Clinic Alcohol Rehabilitation Program: A treatment outcome study. A preliminary report. Cleve Clin Q. 1985;52(2):245–51. Exclusion Code: X4. [PubMed: 4028426]
61.
Connery H, Greenfield S, Livchits V, et al. Training and fidelity monitoring of alcohol treatment interventions integrated into routine tuberculosis care in Tomsk, Russia: The IMPACT effectiveness trial. Subst Use Misuse. 2013;48(9):806–14. 2013-21629-011. First Author & Affiliation: Connery, Hilary. Exclusion Code: X5. [PMC free article: PMC4010131] [PubMed: 23750742]
62.
Corbin WR, Scott C, Leeman RF, et al. Early Subjective Response and Acquired Tolerance as Predictors of Alcohol Use and Related Problems in a Clinical Sample. Alcohol. 2013. Exclusion Code: X6. [PMC free article: PMC3586307] [PubMed: 23347236]
63.
Cornelius JR, Perkins KA, Salloum IM, et al. Fluoxetine versus placebo to decrease the smoking of depressed alcoholic patients. J Clin Psychopharmacol. 1999;19(2):183–4. Exclusion Code: X8. [PubMed: 10211921]
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Cornelius JR, Salloum IM, Cornelius MD, et al. Preliminary report: double-blind, placebo-controlled study of fluoxetine in depressed alcoholics. Psychopharmacol Bull. 1995;31(2):297–303. Exclusion Code: X6. [PubMed: 7491382]
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66.
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67.
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68.
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69.
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71.
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73.
Cutler RB. Abatement of craving in recovering alcoholics: A descriptive analysis. Addict Res Theory. 2005;13(2):111–27. Exclusion Code: X6.
74.
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75.
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76.
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78.
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99.
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105.
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106.
Friedmann PD, Mello D, Lonergan S, et al. Aversion to injection limits acceptability of extended-release naltrexone among homeless, alcohol-dependent patients. Substance Abuse. 2013;34(2):94–6. 2013-13571-004. First Author & Affiliation: Friedmann, Peter D. Exclusion Code: X8. [PMC free article: PMC4394196] [PubMed: 23577900]
107.
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108.
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109.
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Furieri FA, Nakamura-Palacios EM. Gabapentin reduces alcohol consumption and craving: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2007 Nov;68(11):1691–700. Exclusion Code: X9. [PubMed: 18052562]
111.
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