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Scientific Studies Supporting Development of Transcriptomic Points of Departure for EPA Transcriptomic Assessment Products (ETAPs)
Scott Auerbach, Warren Casey, Dan Chang, John Cowden, Sarah Davidson-Fritz, Jeffry Dean, Mike Devito, Logan Everett, Alison H. Harrill, Susan Hester, Michael Hughes, Jason Lambert, Lucina Lizarraga, Roman Mezencev, Grace Patlewicz, Kristina Thayer, Russell S. Thomas, Kelsey Vitense, and Leah Wehmas.
Author Information and AffiliationsContents
- ABBREVIATIONS
- AUTHORS | CONTRIBUTORS
- 1. EXECUTIVE SUMMARY
- 2. BACKGROUND
- 2.1. WORLDWIDE AND DOMESTIC CHEMICAL LANDSCAPE
- 2.2. TOXICITY TESTING DATA LANDSCAPE
- 2.3. HUMAN HEALTH ASSESSMENT LANDSCAPE
- 2.4. DEVELOPMENT OF THE EPA TRANSCRIPTOMIC ASSESSMENT PRODUCT (ETAP) TO ADDRESS THE HUMAN HEALTH ASSESSMENT GAP
- 2.5. VALUE OF INFORMATION (VOI) ANALYSIS OF THE POTENTIAL PUBLIC HEALTH AND ECONOMIC TRADE-OFFS OF ETAP
- 2.6. BOARD OF SCIENTIFIC COUNSELORS (BOSC) SCIENTIFIC REVIEW OF ETAP DEVELOPMENT AND IMPLEMENTATION
- 3. REVIEW OF TRANSCRIPTOMIC DOSE RESPONSE LITERATURE
- 3.1. EPA HISTORY, POLICIES, AND USE OF TRANSCRIPTOMICS
- 3.2. REPRODUCIBILITY OF TRANSCRIPTOMIC DATA
- 3.3. DOSE CONCORDANCE OF TRANSCRIPTIONAL AND APICAL RESPONSES
- 3.4. IMPACT OF EXPOSURE DURATION ON TRANSCRIPTIONAL AND APICAL DOSE CONCORDANCE
- 3.5. IMPACTS OF CHEMICAL MODE-0F-ACTION ON TRANSCRIPTIONAL AND APICAL DOSE CONCORDANCE
- 3.6. SCOPE OF CHEMICAL FUNCTIONAL USE, PROPERTIES, AND TOXICOKINETIC PARAMETERS FOR CHEMICALS WITH TRANSCRIPTIONAL AND APICAL DOSE CONCORDANCE
- 3.7. IMPACTS OF ROUTE OF EXPOSURE AND TISSUE SELECTION ON TRANSCRIPTIONAL AND APICAL DOSE CONCORDANCE
- 3.8. IMPACTS OF TECHNOLOGY PLATFORM ON TRANSCRIPTIONAL AND APICAL DOSE CONCORDANCE
- 3.9. SUMMARY OF TRANSCRIPTIONAL AND APICAL DOSE CONCORDANCE
- 4. DEVELOPMENT OF TRANSCRIPTOMIC POINTS OF DEPARTURE FOR ETAP
- 5. SUMMARY AND CONCLUSIONS
- 6. APPENDIX
- 7. REFERENCES
Final Report
Contributors
Reeder Sams
CCTE Deputy Center Director
Sid Hunter
CCTE/BCTD Division Director
Wayne Cascio
CPHEA Center Director
Kay Holt
CPHEA Deputy Center Director
Samantha Jones
CPHEA Associate Director
Ravi Subramaniam
CPHEA/CPAD/TEABD Branch Chief
Glenn Rice
CPHEA/CPAD/TEABC Branch Chief
John Bucher
NTP/DTT/NIEHS/NIH
Timothy Buckley
EPA/ORD/CCTE
Peter Egeghy
EPA/ORD/CCTE
Katie Paul-Friedman
EPA/ORD/CCTE
Joshua Harrill
EPA/ORD/CCTE
Kristin Isaacs
EPA/ORD/CCTE
Richard Judson
EPA/ORD/CCTE
Jonathan Kaiser
EPA/ORD/CPHEA
Scott Masten
NTP/DTT/NIEHS/NIH
Fred Parham
NTP/DTT/NIEHS/NIH
Dan Petersen
EPA/ORD/CPHEA
Allison Phillips
EPA/ORD/CPHEA
Jon Sobus
EPA/ORD/CCTE
Daniel Villeneuve
EPA/ORD/CCTE
Paul White
EPA/ORD/CPHEA
Antony Williams
EPA/ORD/CCTE
George Woodall
EPA/ORD/CPHEA
Jay Zhao
EPA/ORD/CPHEA
DISCLAIMER: This document has been reviewed in accordance with the U.S. Environmental Protection Agency’s (EPA) peer and administrative review policies and approved for publication. Peer review was performed by the EPA Board of Scientific Counselors and was subject to public comment. Any mention of trade names, products, or services does not imply an endorsement by the U.S. government or the EPA. EPA does not endorse any commercial products, services, or enterprises.
- NLM CatalogRelated NLM Catalog Entries
- Scientific Studies Supporting Development of Transcriptomic Points of Departure ...Scientific Studies Supporting Development of Transcriptomic Points of Departure for EPA Transcriptomic Assessment Products (ETAPs)
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