Contents

• Acknowledgements
• Disclaimer
• Reviewers
• List of Abbreviations and Acronyms
• 1. Executive Summary
• 2. Introduction
• 3. Background
  • 3.1. Development and Implementation of New Approach Methods Under TSCA
  • 3.2. Evaluating Existing Chemicals Under TSCA
  • 3.3. Public Engagement
• 4. Public Information Curation and Synthesis (PICS) Approach
  • 4.1. Overview of the PICS Approach
  • 4.2. What the PICS Approach is Intended to Accomplish
  • 4.3. What the PICS Approach is Not Intended to Accomplish
• 5. A Proof-of-Concept Case Study
  • 5.1. Chemical Substance Selection, Curation and Quality Control
  • 5.2. Scientific Domain Metric Assessment
  • 5.3. Scientific Domain Metric Calculation
  • 5.4. Information Availability Metric
  • 5.5. Results of the Proof-of-Concept Analysis
  • 5.6. Overall Limitations and Long-term Options
• 6. Summary
• 7. Conclusion
• Appendix A. Proof-of-Concept (POC) Subset of the Non-confidential TSCA Active Inventory
• Appendix B. Detailed Information on Data Sources used in the PICS Approach
• Appendix C. Quality Assurance Recommendations to Efficiently Review Datasets to Support Candidate Chemical Identification for TSCA
• Appendix D. Definition of Exposure Pathways for Calculating the Susceptible Population Domain Metric
• Appendix E. Public Information Curation and Synthesis (PICS) Output for Proof-of-Concept (POC) Subset of the Non-confidential TSCA Active Inventory
• Appendix F. Comparison of Individual Scientific Domain Metrics for the POC238 and Non-confidential TSCA Active Inventory
• Appendix G. Information Availability Metric Calculation
• PEER REVIEW PLAN
• EPA Response to External Peer Review of A Proof-of-Concept Case Study Integrating Publicly Available Information to Screen Candidates for Chemical Pre- Prioritization under TSCA (TSCA POC)
• Peer Review Report

Suggested citation:

USEPA 2021. A Proof-of-Concept Case Study Integrating Publicly Available Information to Screen Candidates for Chemical Pre-Prioritization under TSCA. June 2021. U.S. Environmental Protection Agency, Office of Chemical Safety and Pollution Prevention and Office of Research and Development, Washington, DC. EPA/600/R-21-106.