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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
- Discovery of Potent and Highly Selective Inhibitors of GSK3b
- Identification of a small molecule inhibitor of Pseudomonas aeruginosa PvdQ acylase, an enzyme involved in siderophore pyoverdine synthesis
- 3-(2,6-difluorobenzamido)-5-(4-ethoxyphenyl) thiophene-2-carboxylic acid inhibits E.coli UT189 bacterial capsule biogenesis
- Probing Metabolic Requirements for Fungal Virulence — Probe 1
- Identification of selective inhibitors of cdc2-like kinases 1 and 4 (Clk1, Clk4)
- Small Molecule Agonists for the Neurotensin 1 Receptor (NTR1 Agonists)
- A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake - Probe 3
- ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis
- Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Gamma (RORγ)
- ML309: A potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells
- Development of a Selective Chemical Inhibitor for the Two-Pore Potassium Channel, KCNK9
- Selective UBC 13 Inhibitors
- Discovery of Novel General Anesthetics Using Apoferritin as a Surrogate System
- A 2nd Selective Inhibitor of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase (PfG6PDH) - Probe 2
- Discovery of Small Molecule Influenza Virus NS1 Antagonist
- ML302, a Novel Beta-lactamase (BLA) Inhibitor
- Non-covalent triazole-based inhibitors of the SARS main proteinase 3CLpro
- Development of a Selective, Allosteric PLD1/2 Inhibitor in a Novel Scaffold
- Development of a Selective, Allosteric PLD2 Inhibitor
- Discovery and Characterization of a Selective Activator of the G-Protein Activated Inward-Rectifying Potassium (GIRK) Channel
- Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6)
- Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-β)
- Discovery of a novel structural class of M4 positive allosteric modulators: Characterization of ML293, N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicotinamide, with CNS exposure in rats
- Discovery of a novel metabotropic glutamate receptor 4 (mGlu4) positive allosteric modulator (PAM) extended probe: Characterization of ML292, a potent and selective mGlu4 PAM which produces efficacy alone or in combination with L-DOPA in preclinical rodent models of Parkinson's disease
- Selective small molecule activator of the apoptotic arm of the UPR
- Discovery, optimization, and biological activity of the first potent and selective small-molecule agonist series of human relaxin receptor 1 (RXFP1)
- Development of the First Selective mGlu3 NAM from an mGlu5 PAM Hit
- ML285 affects reactive oxygen species’ inhibition of pyruvate kinase M2
- Hepatitis C Virus NS3 Helicase Inhibitor Discovery
- A small molecule pan-inhibitor of Ras-superfamily GTPases with high efficacy towards Rab7
- Screen for Inhibitors of STK33 Kinase Activity
- A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake—Probe 2
- A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake—Probe 1
- Identification of a novel, small molecule activator of KCNQ1 channels
- A Selective Inhibitor of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase (PfG6PDH)
- Identification of a Series of Quinazolinediones as Potent, Selective, Post-Entry Inhibitors of Human Respiratory Syncytial Virus (hRSV) via a Cell-Based High Throughput Screen and Chemical Optimization
- Identification of a Selective Allosteric Agonist of mGlu5
- Identification of Selective Agonists of the Transient Receptor Potential Channels 3 (TRPML3)
- Discovery of ML 267 as a Novel Inhibitor of Pathogenic Sfp phosphopantetheinyl transferase (PPTase)
- Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase
- ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model
- ML264: An Antitumor Agent that Potently and Selectively Inhibits Krüppel-like Factor Five (KLF5) Expression: A Probe for Studying Colon Cancer Development and Progression
- Potent inhibitors of lipid droplet formation
- A Selective Murine Intestinal Alkaline Phosphatase (muIAP) Inhibitor
- Selective Bcl-2 Inhibitor Probes
- Probe Development Efforts to Identify Novel Inhibitors of ABHD10
- Optimization and characterization of a carbamate inhibitor for plasma platelet-activating factor acetylhydrolase (pPAFAH)
- Pure Positive Allosteric Modulators (PAMs) of mGlu5 with Competitive MPEP-Site Interaction
- Extended Probe Characterization: Development of an M4 PAM with Improved Activity and Brain Exposure, while Avoiding Species Bias
- Identification of a novel, small molecule inhibitor of KCNQ2 channels
- Identification of Selective Inhibitors of Phosphofructokinase as Lead Compounds Against Trypanosomiasis
- Optimization and Characterization of a Second Antagonist for G-protein Coupled Receptor 7 (GPR7)
- Probe Development Efforts for an Allosteric Agonist of the Sphingosine 1-phosphate Receptor 3 (S1P3)
- Identification of a Novel Agonist of the Sphingosine 1-phosphate Receptor 4 (S1P4)
- Discovery, SAR, and Biological Evaluation of a Non-Inhibitory Chaperone for Acid Alpha Glucosidase
- Discovery and Development of Small Molecules That Reduce PNC Prevalence
- Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells—Probe 2
- Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 3
- Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 1
- Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction
- Identification of Thyroid Stimulating Hormone Receptor Inverse Agonists
- ML223: A Small Molecule Probe With In Vivo Activity Against Acute Myeloid Leukemia Subtype M4Eo
- Discovery of non-covalent inhibitors of the SARS main proteinase 3CLpro
- Year 4 Reports - Probe Reports from the NIH Molecular Libraries ProgramYear 4 Reports - Probe Reports from the NIH Molecular Libraries Program
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