NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Comparative Effectiveness Review Summary Guides for Consumers [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2005-.
This publication is provided for historical reference only and the information may be out of date.
Is This Information Right for Me?
This information is right for you if
- Your child's health care professional* said that your child has an infantile hemangioma (pronounced IN-fen-tile hee-man-gee-OH-mah) on or under the skin. An infantile hemangioma (IH) on the top layer of the skin used to be called a “strawberry hemangioma” or “strawberry mark.”
- Your child's health care professional said that your child's IH may need treatment.
This information may not be helpful to you if
- Your child's IH is in or on an internal organ. The information in this summary is from research on treatments for IHs on or under the skin.
What will this summary tell me?
This summary will answer these questions:
- What is an infantile hemangioma (IH)?
- How are IHs treated?
- What have researchers found about how well the treatments work?
- What are possible side effects of medicines and laser treatments to treat IHs?
- What should I talk about with my child's health care professional?
Where does the information come from?
Researchers funded by the Agency for Healthcare Research and Quality a Federal Government research agency reviewed studies on medicines and laser treatments for infantile hemangiomas published through June 2015. The report included 148 studies and was reviewed by health care professionals, researchers, experts, and the public. You can read the report at www.effectivehealthcare.ahrq.gov/infantile-hemangioma.
Understanding Your Child's Condition
What is an infantile hemangioma?
An infantile hemangioma (IH) is a birthmark that happens when a group of blood vessels and other cells do not grow normally. The mark starts as a small bump or colored patch on the skin and may grow quickly. Its color depends on how deep in the skin the IH is. Often, you cannot see the IH at birth. The mark starts to appear in the first few weeks of life.
- An IH on the outer layer of skin is usually bright red and raised. This type of IH used to be called a “strawberry hemangioma” or “strawberry mark.”
- An IH that grows under the skin may make the skin look blue or may have no color. Tiny red blood vessels may also show up on the skin.
- Sometimes an IH is both on the outer layer of skin and under the skin.
An IH can form anywhere on the body, but it often forms on the head or neck.
An IH can range in size. It may stay as small as the tip of a crayon. Or, it may grow as big as a baseball or larger. The IH may grow very quickly in the first few months of life and may continue to grow until around 1 year of age or older.
Once the IH reaches its largest size, it usually starts to shrink and fade. It often takes several years for the IH to shrink and fade. The IH may not go away completely, or it may leave a scar.
How common is an IH?
- Out of every 100 babies, about 4 to 5 babies have an IH.
- IHs are more common in white babies.
- Girls have an IH more often than boys.
- Premature babies (those born before 37 weeks of pregnancy) have a higher risk of having an IH.
What problems can an IH cause, and when should an IH be treated?
Most IHs go away on their own over several years with no problems. But, an IH may cause problems in some cases.
- An IH may leave a scar or extra skin in some children.
- »
If your child's IH is in a visible place, such as on the face, talk with your child's health care professional about whether you should consider treatment.
- Sometimes, an IH can blister (ulcerate) or become infected.
- »
An infected IH may hurt and could leave a worse scar.
- »
Signs of an infected IH may include pain, redness, crustiness, discharge, or a bad smell coming from the IH. Call your child's health care professional if your child has any of these symptoms.
- An IH near the eyes, nose, or mouth could cause problems with seeing, breathing, or eating. These problems are rare but may be permanent if the IH is not treated early.
- »
For these more severe IHs, your child's health care professional may send your child to a specialist.
If your child's IH does not start to shrink and go away on its own, talk with your child's health care professional about whether treatment may be needed.
Understanding Your Options
How is an IH treated?
Most IHs do not need treatment and will go away on their own. Your child's health care professional may check the IH over time to make sure it is shrinking and is not causing any problems.
If the IH needs treatment, your child's health care professional will probably first suggest a medicine. Laser treatments can be used to treat IHs but are not used as often.
In some cases, surgery to remove the IH may be needed. Usually, health care professionals only suggest surgery if the IH is likely to cause serious problems (such as problems with seeing, breathing, or eating) and if medicines did not work to treat the IH.
Medicines
The chart on the next page gives information about medicines to treat IH. Which medicine your child's health care professional recommends depends on many things, such as your child's age and the size and location of your child's IH. Treatment with medicines taken by mouth or gel drops put on the IH usually lasts about 9 to 15 months.
Medicine (Brand Name) | How It Is Taken | More Information |
---|---|---|
Beta-Blockers | ||
Propranolol (Hemangeol™) | Taken by mouth daily |
|
Timolol (Timoptic-XE®) | Gel drops put on the IH daily | |
Atenolol (Tenormin®) | Taken by mouth daily | |
Nadolol (Corgard®) | ||
Steroids | ||
Methylprednisolone (Medrol®) | Taken by mouth daily |
|
Prednisolone (Flo-Pred®, Prelone®) | ||
Triamcinolone (Kenalog®) | Shot given monthly** |
- *
The FDA approves medicines to treat certain conditions. A health care professional may choose to prescribe a medicine for a condition other than what the FDA has approved it for. This is called “off-label” use, and health care professionals often prescribe medicines this way.
- **
The number of shots needed to treat an IH depends on the specific type of IH your child has. Talk with your child's health care professional about how many shots your child may need.
What have researchers found about how well medicines work to treat an IH?
Beta-Blockers
- Propranolol (Hemangeol™) helps treat the IH in at least 9 out of every 10 children.
- »
Fewer than 2 out of every 10 children treated with propranolol (Hemangeol™) needed additional propranolol treatment because the IH started to grow again.
- Timolol (Timoptic-XE®) gel drops may help treat the IH in at least 6 out of every 10 children, but more research is needed to know this for sure.
- Atenolol (Tenormin®) and nadolol (Corgard®) may help treat IHs as well as propranolol (Hemangeol™) does, but more research is needed to know this for sure.
Steroids
- Methylprednisolone (Medrol®) and prednisolone (Flo-Pred®, Prelone®) help treat the IH in at least 4 out of every 10 children.
- Triamcinolone (Kenalog®) may help treat the IH in at least 5 out of every 10 children, but more research is needed to know this for sure.
- The beta-blocker popranolol (Hemangeol™) works better than steroids to treat IHs.
What are the possible side effects of medicines to treat an IH?
Medicine (Brand Name) | Possible side effects listed by the FDA include: |
---|---|
Beta-Blockers | |
Propranolol (Hemangeol™) by mouth Timolol* (Timoptic-XE®) gel drops Atenolol (Tenormin®) by mouth Nadolol (Corgard®) by mouth |
|
Steroids | |
Methylprednisolone (Medrol®) by mouth Prednisolone (Flo-Pred®, Prelone®) by mouth Triamcinolone (Kenalog®) shot |
|
- *
Because timolol (Timoptic-XE®) is put on the skin instead of taken by mouth or as a shot, it may cause fewer side effects.
Note: It is important to talk with your child's health care professional about the safety of medicines to treat your child's IH. According to the FDA:
- »
Beta-blockers should not be taken by children who have:
- –
Wheezing or other breathing problems
- –
A slow heartbeat
- –
Certain heart problems
- »
Propranolol (Hemangeol™) should not be taken by children who:
- –
Weigh less than 4.5 pounds
- –
Have low blood pressure
- »
The steroid shot triamcinolone (Kenalog®) should not be taken by children who are younger than 3 weeks old.
Laser Treatments
Your child's health care professional may suggest laser treatments. Laser treatments use focused light energy to help treat the IH.
Possible side effects of laser treatments include:
- A scar
- Changes in skin color (light spots or dark spots*)
- Tinning of the skin
- Bleeding
- Blistering
- Infection
What have researchers found about how well laser treatments work to treat an IH?
- Laser treatments appear to help treat IHs, but more research is needed to know this for sure.
- More research is needed to know how laser treatments compare with medicines to treat IHs.
Making a Decision
What should I think about when deciding?
There are several things to think about when deciding whether to treat your child's IH, and if so, which treatment might be best. You may want to talk with your child's health care professional about:
- If treatment is needed or if the IH will likely go away on its own without any problems
- If the IH is treated, which treatment may be best for your child
- The possible side effects of treatment
- The cost of the treatment
Ask your child's health care professional
- Do you recommend treating my child's IH or letting it go away on its own?
- How long might it take for the IH to go away on its own?
- Do you think my child's IH could cause any problems if it is not treated?
- Is the IH likely to leave a scar?
- If we decide to treat my child's IH, when should treatment begin?
- Which treatment might be best? Why?
- If a medicine might help my child, which one do you think may be best?
- How long might my child have to take the medicine?
- What short-term and long-term side effects should I watch for?
- Might laser treatments help my child?
- How many laser treatments might my child need?
- What are the possible benefits and side effects of laser treatments?
- Might my child need surgery?
- What are the possible benefits and risks of surgery?
Source
The information in this summary comes from the report Diagnosis and Management of Infantile Hemangioma, January 2016. The report was produced by the Vanderbilt University Evidence-Based Practice Center through funding by the Agency for Healthcare Research and Quality (AHRQ).
For a copy of the report or for more information about AHRQ, go to www.effectivehealthcare.ahrq.gov/infantile-hemangioma.
Additional information came from the MedlinePlus® Web site, a service of the National Library of Medicine and the National Institutes of Health. This site is available at www.medlineplus.gov.
This summary was prepared by the John M. Eisenberg Center for Clinical Decisions and Communications Science at Baylor College of Medicine, Houston, TX. Parents and caregivers of children with infantile hemangiomas reviewed this summary.
Footnotes
- *
Your child's health care professional may include your primary care physician; pediatrician; skin doctor (dermatologist); ear, nose, and throat doctor (otolaryngologist); eye doctor (ophthalmologist); blood doctor (hematologist); surgeon; nurse practitioner; or physician assistant.
- *
Researchers found that light spots are more common than dark spots.
- Review Treating Disruptive Behavior Disorders in Children and Teens: A Review of the Research for Parents and Caregivers.[Comparative Effectiveness Revi...]Review Treating Disruptive Behavior Disorders in Children and Teens: A Review of the Research for Parents and Caregivers.John M. Eisenberg Center for Clinical Decisions and Communications Science. Comparative Effectiveness Review Summary Guides for Consumers. 2005
- Burden of Infantile Hemangioma on Family: An International Observational Cross-Sectional Study.[Pediatr Dermatol. 2017]Burden of Infantile Hemangioma on Family: An International Observational Cross-Sectional Study.Cazeau C, Blei F, Gonzáles Hermosa MDRF, Cavalli R, Boccara O, Fölster-Holst R, Berdeaux G, Delarue A, Voisard JJ. Pediatr Dermatol. 2017 May; 34(3):295-302. Epub 2017 Apr 6.
- Review Infantile hemangiomas, complications and treatments.[Semin Cutan Med Surg. 2016]Review Infantile hemangiomas, complications and treatments.Cheng CE, Friedlander SF. Semin Cutan Med Surg. 2016 Sep; 35(3):108-16.
- Review Clinical and economic impact of surgery for treating infantile hemangiomas in the era of propranolol: overview of single-center experience from La Paz Hospital, Madrid.[Eur J Pediatr. 2019]Review Clinical and economic impact of surgery for treating infantile hemangiomas in the era of propranolol: overview of single-center experience from La Paz Hospital, Madrid.López-Gutiérrez JC. Eur J Pediatr. 2019 Jan; 178(1):1-6. Epub 2018 Nov 12.
- Social Impact of Facial Infantile Hemangiomas in Preteen Children.[JAMA Otolaryngol Head Neck Sur...]Social Impact of Facial Infantile Hemangiomas in Preteen Children.Costa VA, Haimowitz R, Cheng YI, Wang J, Silverman RA, Bauman NM. JAMA Otolaryngol Head Neck Surg. 2016 Jan; 142(1):13-9.
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