Summary of Critical Appraisal of Included Clinical and Cost Studies

Strengths

Limitations

SIGN50⁵

Dental Pain

Jena et al., 2013⁶

Appropriate and clearly focused research question
Initial pain was similar between groups at baseline
Inclusion criteria, study interventions, outcome measures clearly described

Randomization and concealment methods were not adequately described
Blinding procedures were not adequately described
Baseline patient characteristics were not well reported
Unclear whether all patients completed the study and if the analysis was based on intention to treat.
None of the results demonstrated statistical significance

Aggarwal, 2010⁷

Appropriate and clearly focused research question
Only difference between groups is treatment under investigation
Randomization and concealment methods were well described
Blinding procedures were well described
Baseline patient characteristics were reported
Power and sample size calculation provided
Inclusion criteria, study interventions, outcome measures clearly described
Low discontinuation rate

None of the results demonstrated statistical significance

Non-Dental/Non-Cancer

Ortiz, 2010⁸

Appropriate and clearly focused research question

Randomization and concealment methods were not adequately described
Blinding procedures were not adequately described
Baseline patient characteristics were not well reported
Unclear how many patients were originally randomized in the study
Statistical analyses methods not provided
Exclusion criteria not provided

Kaeding et al., 2004⁹

Appropriate and clearly focused research question
Randomization methods were well described
Baseline patient characteristics were reported

Patients were not blinded, only nurse assessor was blinded
Statistical measures of dispersion and confidence intervals were not provided
None of the results demonstrated statistical significance
Only exclusion criteria was specified

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Bookshelf ID: NBK254123

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Ketorolac for Pain Management: A Review of the Clinical Evidence [Internet].

APPENDIX 3Summary of Critical Appraisal of Included Clinical and Cost Studies

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Strengths	Limitations
SIGN50⁵
Dental Pain
Jena et al., 2013⁶
Appropriate and clearly focused research question Initial pain was similar between groups at baseline Inclusion criteria, study interventions, outcome measures clearly described	Randomization and concealment methods were not adequately described Blinding procedures were not adequately described Baseline patient characteristics were not well reported Unclear whether all patients completed the study and if the analysis was based on intention to treat. None of the results demonstrated statistical significance
Aggarwal, 2010⁷
Appropriate and clearly focused research question Only difference between groups is treatment under investigation Randomization and concealment methods were well described Blinding procedures were well described Baseline patient characteristics were reported Power and sample size calculation provided Inclusion criteria, study interventions, outcome measures clearly described Low discontinuation rate	None of the results demonstrated statistical significance
Non-Dental/Non-Cancer
Ortiz, 2010⁸
Appropriate and clearly focused research question	Randomization and concealment methods were not adequately described Blinding procedures were not adequately described Baseline patient characteristics were not well reported Unclear how many patients were originally randomized in the study Statistical analyses methods not provided Exclusion criteria not provided
Kaeding et al., 2004⁹
Appropriate and clearly focused research question Randomization methods were well described Baseline patient characteristics were reported	Patients were not blinded, only nurse assessor was blinded Statistical measures of dispersion and confidence intervals were not provided None of the results demonstrated statistical significance Only exclusion criteria was specified