LITERATURE SEARCH STRATEGY

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Rivaroxaban (Xarelto): Treatment of Venous Thromboembolic Events (Deep Vein Thrombosis [DVT], Pulmonary Embolism [PE]) and Prevention of Recurrent DVT and PE [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Aug.

Rivaroxaban (Xarelto): Treatment of Venous Thromboembolic Events (Deep Vein Thrombosis [DVT], Pulmonary Embolism [PE]) and Prevention of Recurrent DVT and PE [Internet].

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APPENDIX 2LITERATURE SEARCH STRATEGY

OVERVIEW
Interface:	Ovid
Databases:	Embase 1974 to present MEDLINE Daily and MEDLINE 1946 to present MEDLINE In-Process & Other Non-Indexed Citations Note: Subject headings have been customized for each database. Duplicates between databases were removed in Ovid.
Date of Search:	June 12, 2013
Alerts:	Weekly search updates until October 16, 2013
Study Types:	No search filters were applied
Limits:	No date or language limits were used Conference abstracts were excluded
SYNTAX GUIDE
/	At the end of a phrase, searches the phrase as a subject heading
.sh	At the end of a phrase, searches the phrase as a subject heading
exp	Explode a subject heading
*	Before a word, indicates that the marked subject heading is a primary topic; or, after a word, a truncation symbol (wildcard) to retrieve plurals or varying endings
adj	Requires words are adjacent to each other (in any order)
.ti	Title
.ab	Abstract
.hw	Heading Word; usually includes subject headings and controlled vocabulary
.rn	CAS registry number
pmez	Ovid database code; MEDLINE In-Process & Other Non-Indexed Citations, MEDLINE Daily and Ovid MEDLINE 1946 to present
oemezd	Ovid database code; Embase 1974 to present, updated daily

MULTI-DATABASE STRATEGY
Line #	Search Strategy
1	(rivaroxaban* or Xarelto* or BAY 59-7939 or BAY59-7939 or BAY597939 or BAY 597939).ti,ot,ab,sh,rn,hw,nm. or (366789-02-8 or 9NDF7JZ4M3).rn,nm.
2	exp Pulmonary embolism/ or ((lung* or pulmonary) adj4 (emobol* or microembol* or thromboembol*)).ti,ab.
3	exp Venous Thrombosis/ or Venous Thromboembolism/ or (Thrombosis/ and Veins/)
4	((thrombotic or thromboembolic* or thrombo-embo* or thrombos* or thromboembolis* or thrombus* or DVT or phlebothrombos* or thrombophlebitis) adj3 (vein* or venous)).ti,ab.
5	(blood adj clot* adj3 (vein* or venous)).ti,ab.
6	1 and (2 or 3 or 4 or 5)
7	6 use pmez
8	rivaroxaban/ or (rivaroxaban or Xarelto* or BAY 59-7939 or BAY59-7939 or BAY597939 or BAY 597939).ti,ab.
9	Lung embolism/ or ((lung or pulmonary) adj4 (emobol* or microembol* or thromboembol*)).ti,ab.
10	Deep vein thrombosis/ or Vein thrombosis/ or Venous thromboembolism/ or (Thrombosis/ and *Vein/)
11	((thrombotic or thromboembolic* or thrombo-embo* or thrombos* or thromboembolis* or thrombus* or DVT or phlebothrombos* or thrombophlebitis) adj3 (vein* or venous)).ti,ab.
12	(blood adj clot* adj3 (vein* or venous)).ti,ab.
13	8 and (9 or 10 or 11 or 12)
14	13 use oemezd
15	14 not conference abstract.pt.
16	7 or 15
17	remove duplicates from 16

OTHER DATABASES
PubMed	Same MeSH, keywords, limits, and study types used as per MEDLINE search, with appropriate syntax used
Trial registries (Clinicaltrials.gov and other)	Same keywords and limits used as per MEDLINE search

Grey Literature

Dates for Search:	June 3 to 7, 2013
Keywords:	Xarelto, rivaroxaban, venous thromboembolism, deep vein thrombosis, pulmonary embolism
Limits:	No date or language limits used

Relevant websites from the following sections of the CADTH grey literature checklist, “Grey matters: a practical tool for evidence-based searching” (http://www.cadth.ca/en/resources/finding-evidence-is/grey-matters) were searched:

health technology assessment agencies
health economics
clinical practice guidelines
drug and device regulatory approvals
advisories and warnings
databases (free)
Internet search.

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Bookshelf ID: NBK344328

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Rivaroxaban (Xarelto): Treatment of Venous Thromboembolic Events (Deep Vein Thrombosis [DVT], Pulmonary Embolism [PE]) and Prevention of Recurrent DVT and PE [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Aug. APPENDIX 2, LITERATURE SEARCH STRATEGY.