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Guthrie B, Rogers G, Livingstone S, et al. The implications of competing risks and direct treatment disutility in cardiovascular disease and osteoporotic fracture: risk prediction and cost effectiveness analysis. Southampton (UK): National Institute for Health and Care Research; 2024 Feb. (Health and Social Care Delivery Research, No. 12.04.)

Cover of The implications of competing risks and direct treatment disutility in cardiovascular disease and osteoporotic fracture: risk prediction and cost effectiveness analysis

The implications of competing risks and direct treatment disutility in cardiovascular disease and osteoporotic fracture: risk prediction and cost effectiveness analysis.

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List of abbreviations

ADE

adverse drug event

AIC

Akaike information criterion

AUROC

area under the receiver operating curve

BMI

body mass index

BWS

best–worst scaling

CCI

Charlson Comorbidity Index

CEA

cost-effectiveness analysis

CG181

Clinical Guideline 181

CI

confidence interval

CKD

chronic kidney disease

CPRD

Clinical Practice Research Datalink

CRISK

competing mortality risk model

CRISK-CCI

competing mortality risk model with Charlson Comorbidity Index

CVD

cardiovascular disease

DTD

direct treatment disutility

eGFR

estimated glomerular filtration rate

EQ-5D-3L

EuroQol-5 Dimensions, three-level version

GAM

generalised additive model

GP

general practitioner

HES

Hospital Episode Statistics

HR

hazard ratio

HSE

Health Survey for England

HTA

Health Technology Assessment

ICD-10

International Statistical Classification of Diseases and Related Health Problems, Tenth Revision

ICER

incremental cost-effectiveness ratio

mCCI

modified Charlson Comorbidity Index

MI

myocardial infarction

MOF

major osteoporotic fracture

MSE

minor side effect

NHB

net health benefit

NICE

National Institute for Health and Care Excellence

NIHR

National Institute for Health and Care Research

NNT

number needed to treat

ONS

Office for National Statistics

OR

odds ratio

PAD

peripheral arterial disease

PICOS

population, intervention, comparator, outcome, study type

QALY

quality-adjusted life-year

QS149

Quality Standard 149

SA

stable angina

SBP

systolic blood pressure

SE

standard error

SHARE

Scottish Health Research Register

SSE

severe side effect

TA464

Technology Appraisal 464

TC : HDL

total cholesterol: high-density lipoprotein ratio

TIA

transient ischaemic attack

TTO

time trade-off

UA

unstable angina

Copyright © 2024 Guthrie et al.

This work was produced by Guthrie et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This is an Open Access publication distributed under the terms of the Creative Commons Attribution CC BY 4.0 licence, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. See: https://creativecommons.org/licenses/by/4.0/. For attribution the title, original author(s), the publication source – NIHR Journals Library, and the DOI of the publication must be cited.

Bookshelf ID: NBK601063
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