Conserved Protein Domain Family
COG5347

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COG5347: COG5347 
GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
Statistics
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PSSM-Id: 227651
Aligned: 14 rows
Threshold Bit Score: 191.531
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
19112800   1 MSGRRNETAIRELVQSVSGNNLCADCSTRG-VQWASWNLGIFLCLRCATIHRKLG---THVSKVKSISLDEWSNDQIEKM 76  fission yeast
19173494  20 VLDKSSVNRFFKYIRMQSNNKRCADCNNPS-PIWVTVTYGFFICTECAAKHRELG---VGTTKVKSTILDTWSLSELRRV 95  Encephalitozoon cun...
19074855   1 MGMN--FNKEVKALREIEENKKCADCSAPS-PPWTSVTYGIFICFDCASVHRSLG---VKTSFVKSVNLDIWDEKEYLFM 74  Encephalitozoon cun...
1723528    2 TATKEESQKLLTSLRSQRDNKVCFDCGAKN-PTWSSTTFGIYLCLDCSAAHRNMGvhiSFVRFLRSTVLDSWTYAQLRVM 80  fission yeast
19114360   9 KESN---ALVLKSLLREPYNKVCADCKRNEqPRWASWNLGVFICIRCSGVHRSLG---VHVSRVKSVDLDSWTDEQTENM 82  fission yeast
15213970 664 kkqtkspsLVKTLKEMHSSDQSCADCNTTArVEWCAINFPVVLCIDCSGIHRSLG---THITKIRSLTLDKFNPETVDLL 740 fission yeast
19075686   1 ------MSYKLDQLTRLPENKKCFDCDAPN-PQWASCNLGIFICLDCSGQHRGLG---VEKSFVRSITMDNWSERQVKMM 70  fission yeast
462172     4 WKVDPDTRRRLLQLQKIGANKKCMDCGAPN-PQWATPKFGAFICLECAGIHRGLG---VHISFVRSITMDQFKPEELLRM 79  baker's yeast
6320732  164 AGASNRDELLSIVRKIDKSNLKCCDCGSTAtVEWVSINLLCILCIKCSGVHRSLG---SHISKIRSLTLDNFTSLELMHL 240 baker's yeast
731803     1 MSTSVPVKKALSALLRDPGNSHCADCKAQLhPRWASWSLGVFICIKCAGIHRSLG---THISKVKSVDLDTWKEEHLVKL 77  baker's yeast
19112800  77 KH--WGNINANRYWNPNPLS-HP--LPTNALSDEHVMEKYIRDKYERKLFLDEnhstnskpp----slpprtksSSQSSP 147 fission yeast
19173494  96 YV--SGNSNAPKLGKVTDLR-T---KYTKAAWYSKVVDELSGKSEMDEPGTLF--------------------------- 142 Encephalitozoon cun...
19074855  75 KH--GSNEKFRRFLEQHRLVg----REMNEIYNNNQIKRYAAEIKGLVVKEMG---------------------EGAFNG 127 Encephalitozoon cun...
1723528   81 RV--GGNENARNYFKRHGGVsLLnsKDCRLKYSSKTAKQYLEKLKSLAVEDEAnypdildmdflsnthegssaaDTTNED 158 fission yeast
19114360  83 TR--WGNERANLYWEAKLAG------G--HVPSDSKIATFIKTKYEFKKWVLY---------------------PEIPSP 131 fission yeast
15213970 741 YA--TGNSFVNEIYEGGITD-----WKIKNFENQERRVQFVKDKYLYKRFIKS---------------------SFS--- 789 fission yeast
19075686  71 EV--GGNSNAKTFLSTDPMFsAA--GSIREKYNTDIAEDLRQKIRAEVDGVEWvk------------------vDRPKSV 128 fission yeast
462172    80 EK--GGNEPLTEWFKSHNIDlS---LPQKVKYDNPVAEDYKEKLTCLCEDRVFeereh------------ldfdASKLSA 142 baker's yeast
6320732  241 LQnnVSNSNVNAIYESNLRNfPV--KKITANSDDSERSKFIIDKYQFKKFVID---------------------SNQGRE 297 baker's yeast
731803    78 IQf-KNNLRANSYYEATLAD--E--LKQRKITDTSSLQNFIKNKYEYKKWIGD---------------------LSSIEG 131 baker's yeast
19112800 148 MASTSTSKSRYADSLSTLHDMGFSDDSVNTHALEETNGDVTRAIEKIVQHGSskpqKPSTLTSTKST-IKLVSARLKKRN 226 fission yeast
19173494 143 -----------IDNLSKRTERALEPRKIEERRMPRFSDSDAKYVEEKSTVAEk---ELRELTESNTNmDRPVTIKRNSLP 208 Encephalitozoon cun...
19074855 128 --------LRTNAVPKGSEDSEGWKRSSMDSVHRSKREYNTLGLESISSGS-----LHNSITSTLSIvGNAIFTGAKTIT 194 Encephalitozoon cun...
1723528  159 DDFFSAWDKASVKKSDDNLDDKTDLASTSSSVVVESGEKDEPVVVTEEKTMVsppsRPDSTSTTKSKtSSISSARARPIR 238 fission yeast
19114360 132 ETLKPEQNTRPVSEVNASLDLNTASRSSSAHSVKSTSSATVTNVTSKKEAIS----ATTSLAQSSPN-LASLSKQPSTVH 206 fission yeast
15213970 790 -----------HDPNTGLLESIEHSNLKEAVLCLALGADVNYQRAV-----------VKALLKNN-----YLIAELLTLN 842 fission yeast
19075686 129 SSHASVTSSSTVPTIPSVSKEANDKYFAKLGSINSQRPDDLPPSQGGRYQGFg---SSNSVNPNSSAr-NNGGSFLDQLS 204 fission yeast
462172   143 TSQTAASATPGVAQSREGTPLENRRSATPANSSNGANFQKEKNEAYFAELGKknqsRPDHLPPSQGGkYQGFGSTPAKPP 222 baker's yeast
6320732  298 ASLKSLIKAIHLDSVFMMQRAIAQSKYSLRELTASEKEQNDLNHSSIFQYSL----KHYEIVDGTP---IFFITEFLLCN 370 baker's yeast
731803   132 ----------LNDSTEPVLHKPSANHSLPASNARLDQSSNSLQKTQTQPPS-----HLLSTSRSNT---SLLNLQVSSLS 193 baker's yeast
19112800 227 KNLSVhfedgtkpgdAYEVTGDTRAASptlnpFEQMMAMTNQGMSVSPGVETTSSPFFTAPVEPNQPLQPLRPSMTGPVP 306 fission yeast
19173494 209 SLRTS----------E-KRGFNVESTG-----SDAKKLGFGALNLLKDGKDNPSSEKGESPKVCKDPFCQDESK------ 266 Encephalitozoon cun...
19074855 195 SKTVEy--------gGIVVNSTKSIIK------DSSPSLTSIFKKKEPTPKDHSKVSGRTEACGRSDKWD---------- 250 Encephalitozoon cun...
1723528  239 ASSRPtask---lgaSRPQKLGIKKANadidfDEFEKAVLSSESAPTKKPAAVASKESTVDTLVDNGVEEVKESTSTTVQ 315 fission yeast
19114360 207 APSTRqr------dlKSSILSLYASPRpq---vSSSSITTNATYQNLPSPVSTSTTSSQPYGAFHQPATTGSSFVADKWK 277 fission yeast
15213970 843 GASLN----------VDEVTMETLSAR------AQAFVMNRATP------------------------------------ 870 fission yeast
19075686 205 SNPVS----------ALSHGWNMFSRS-----VSQQIQDVQDPETRKDYMNAINNFSSNVQEGAKQSFTQLKSFLDENVY 269 fission yeast
462172   223 QERSAgssntlslenFQADPLGTLSRGwglfsSAVTKSFEDVNETVIKPHVQQWQSGELSEETKRAAAQFGQKFQETSSY 302 baker's yeast
6320732  371 GIHID----------NLPKITTNWSPK------VLEYWETKLEMYGTFQAVNTSRPRSGPHLNMHSNVDS-ASSYNKKHD 433 baker's yeast
731803   194 KTTSN----------TSVTSSATSIGA------ANTKTGNRVGEFGQRNDLKKSILSLYSKPSAQTQSQ--NSFFTSTTP 255 baker's yeast
19112800 307 ssmgseATLNMPSTYGIDSNLYTNSNSSSIVQNPLQPARTGPAAINYnYTTNYS 360 fission yeast
19173494     ------------------------------------------------------     Encephalitozoon cuniculi
19074855     ------------------------------------------------------     Encephalitozoon cuniculi
1723528  316 gk--pvKPVLKSAASAKSTKSDDSNLNANFARLGFGQFAAASNARAKaAAKARE 367 fission yeast
19114360 278 ------MPMFTSNVTSAQP-----SARASPVQSNSSRPRSSLDSKIInSHDVWK 320 fission yeast
15213970     ------------------------------------------------------     fission yeast
19075686 270 s----eNPQNTRGTYDAEIDSPYSALAASPPPEDYSKKNFDKHD---------- 309 fission yeast
462172   303 g-----FQAFSNFTKNFNGNAEDSSTAGNTTHTEYQKIDNNDKKNEQdEDKWDD 351 baker's yeast
6320732  434 ------LRVNIPERSASASKRWSLSSIPKSSQNLMSPTNLLTMHKSL-KLAKKD 480 baker's yeast
731803   256 ------QPCNTPSPFVNTG----ITATNNNSMNSNSSSNISLDDNEL-FKNVWS 298 baker's yeast
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