Conserved Protein Domain Family
ROM1

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COG5422: ROM1 
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
Statistics
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PSSM-Id: 227709
Aligned: 5 rows
Threshold Bit Score: 1068.74
Created: 7-Oct-2002
Updated: 23-Jan-2015
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1710635     4 TNVDSLGDRNDIYSQIFGVERRpdsfatfdSDSHg---dISSQLLPNriENIQNLnvllsediANDIIIAKQrrrsgvea 80   baker's yeast
19173015      --------------------------------------------------------------------------------      Encephalitozoon c...
19115765    1 -------------------------------------------------------------------MLRNG-------- 5    fission yeast
19075616    6 PNALGVNESSRAYEEIFGAPRKrepartvsTPAFmepapVSKKPLPPptRRLPRKplpfrstsLQPPSSQPPappthqre 85   fission yeast
1710634     1 MNSNELDLRNKYFYEIFGKKRK--------SDTS-----TPTQLFSG--SKVQTN--------INEISITND-------- 49   baker's yeast
1710635    81 aiDDSDIPNNEMKGKSSNYILSQQTNIKEVpdtqslssadntpvSSPKKARDATSSHPIVHAKSMSHIYSTSNSASrqak 160  baker's yeast
19173015      --------------------------------------------------------------------------------      Encephalitozoon c...
19115765    6 --AQNGNINSESHESFGKAAKGFRIFSSFS--------------SSQKLFQRR-SSGSITHSPTALSSTTSLNEND---- 64   fission yeast
19075616   86 asPVKNIEHSESFPSVFGTSNNHQIVPLTLkdgndfgalyaslnTTPHFPQVSNHAPNNSNSPSLTWHTSSGDDSNqnpf 165  fission yeast
1710634    50 --EDEDSTEDENKASLKDYTLGHDTGARYR--------------IAPDCSSHQLKASPVLHIS--TNLNSSPQSFT---- 107  baker's yeast
1710635   161 hyNDHplppMSPRNEVYQKNKSTtafvpkrkpslpqlalaglkKQSSFSTGSASTTPTQARKSPLQgfgffsrPSSKdlh 240  baker's yeast
19173015      --------------------------------------------------------------------------------      Encephalitozoon c...
19115765   65 --GNH----FRPAS-SLSFSPSS---------------------LSRKDSGPGDGLEVNKKNNFYR-------RSSS--- 106  fission yeast
19075616  166 fvRRQsqssTSPVSDSVDENLLSavssv----------tesveTNLHLDQNYPYGSPVRSSKNPFLssnsrlpTDDSsht 235  fission yeast
1710634   108 --GDQ----ISPTNKKISINDST--------------------RQDKGNSCTTTSSPSQKRSNVLL-------PHVR--- 151  baker's yeast
1710635   241 eqhqhhQHIQHNNINnhnnnNTNNNGAHyqVGSSNSNYPQHSHSISS---RSMSLNSstlkNiasSFQSKTSNSRkatq- 316  baker's yeast
19173015      --------------------------------------------------------------------------------      Encephalitozoon c...
19115765  107 --------------------TDDFGISH-------ARSRKEIQSLGR--------------P---HTRQSFSVSD----- 137  fission yeast
19075616  236 vgshsfTSGTHPPIVssnsaFTLPNAVTpaAQAPLIRSVSEYPANVSppaQSLQLPKstsnPadlHLSIASASSHknifs 315  fission yeast
1710634   152 ------KHSSPSLLS-----FSKNSGSH--MGDPNQLSTPPTPKSAG---HTMELHS--------SFNGKHSSSS----- 202  baker's yeast
1710635   317 kydiTSNPFSDPHHHHHHHHSSNSHSSlnNVHGSgnsssvmgsssniglglktrvssTSLALKRYTSVSGTSLSsprRSS 396  baker's yeast
19173015      --------------------------------------------------------------------------------      Encephalitozoon c...
19115765  138 ----VSNGSSYPNIRKNSVHVNAPMPS--FPEGS-----------------------TAVLLKHHSGSKSASAI---S-N 184  fission yeast
19075616  316 gldvFSNVFHGPSTTLRDREHDMRNRS--FDHSTlahyeavkqq----rlgveptarSFTLSSYKSRASGNSLIndrSST 389  fission yeast
1710634   203 ----TSSLFALESLKTQNRRSSNSSN-----HSS--------------------------QYRRHTNQHQRHHS---RSK 244  baker's yeast
1710635   397 MTPLSASRPVMSASSK---KPQVYPALLSRVATKFKSSIQLGEHKKDGLVYRDAFTGQQAVDVICAIIRTSDRNLALLFG 473  baker's yeast
19173015    1 ------------------------------------MLTLMSRSRKLIEALEEIFE-SEKSYIRDLILWERDFRIWVLNC 43   Encephalitozoon c...
19115765  185 IAPSHSN----STSSR---RPYIHPAFLSQVAVEFRKRLNIGDRVKDGLLYKDAFLGSEAVDVLMHIVRTTDRNLALLLG 257  fission yeast
19075616  390 TTPTFVNSEASSPVHKnkrRRRIYAALLSRVASELLDRLQLGDITKDGLIYSNAFTGDHAVTVLMGIIHTSDRNLALLVG 469  fission yeast
1710634   245 SSPVSLTEISMIKGT-----PLVYPALLSLIAIKFKQTIKLSTHKKMGLLYRDSFTGKQAIDTLCLIIGSLDRNLGMLIG 319  baker's yeast
1710635   474 RSLDAQKLFHDVVYEHRLRDSPHEVYEFT-------DNSRFTgtgstNAHDPlmllpnsssfnsgnhsypnsgmvPSSST 546  baker's yeast
19173015   44 PLFSSPKVKYEICDRVFINMDRIQRLHQR-------IYEDMR------KMN--------------------------FGA 84   Encephalitozoon c...
19115765  258 RALDSQKMFHDVTYSHRLRDSLKEVYQYRriispppGLSSMDsngssIENNFlytkrrantsdsfdsvlsdssttPTISS 337  fission yeast
19075616  470 RSLDAQKFIHDVTYDHRLRDSHREIYQLQ-------GTGYRP-----FLRAN-----------------------DNASI 514  fission yeast
1710634   320 KSLEAQKLFHDVLYDHGVRDSVLEIYELS-------SESIFM------AHQ------------------------SQSST 362  baker's yeast
1710635   547 SSLNSDQATLTGSrlhmSSSLSQQKNPAAIHNVNGVFTLLAECYSPTCT-RDALCYSISCPRRLEQQARLNLKPNGGLKR 625  baker's yeast
19173015   85 GFETMGKDALNNA--------NEHATEKAEG--SSANLRQLECVSIYERyVDEFTVYYEYVRRLPKAEFELEKLMYRYPD 154  Encephalitozoon c...
19115765  338 SVQVNSLAFITSSl---SAITKEPEAPETEYNPHGVFTLLTECYSSTCS-RNRLCYSISCPRRLEQQARLHLKVQPVLSG 413  fission yeast
19075616  515 NNKNHHKELEDNE----SGTRISPSTLGDTSFPNGIFTLLTHCYSPTCA-KDHPCYSISCPRRLEQQHRLFAKMRANTEQ 589  fission yeast
1710634   363 SIAN----TFSSS----SSSVNSLRTKTEIY---GVFVPLTHCYSSTCS-LEKLCYSISCPNRLQQQANLHLKLGGGLKR 430  baker's yeast
1710635   626 NISMALDDDDEEKPSWTSSVSKEDWENLPKKEIKRQEAIYEVYITEKNFVKSLEITRDTFMKTLAETNIISADIRKNFIK 705  baker's yeast
19173015  155 FASGVKD-FLEQKNAEFLGIKHFLYR--PSQKLARYPLLLKAVVKN-----EEGGLKDAYERLVESFKAIAKNADREFNK 226  Encephalitozoon c...
19115765  414 GSTSITDKQEEDHRLWSENVPKQVVDQIDVREWKRQEIIFEVIYTERDFVRDLEYIRDFWIKPLSTSNVIPENNRQQFIR 493  fission yeast
19075616  590 SSSLAFD--DKEQKLWIHSVPQEIAYSVSDRERKRQEVICEVIYTERDFVKDLEYLRDYWIKPLWASSCIPERKKEKFIR 667  fission yeast
1710634   431 NISLALDKEDDERISWTNSVPKSVWESLSKQQIKRQEAIYELFTTEKKFVKSLEIIRDTFMKKLLETNIIPSDVRINFVK 510  baker's yeast
1710635   706 HVFAHINDIYSVNRRFLKALTDRQRSSPVVRGIGDIVLRFIPFFEPFVSYVASRPYAKYLIETQRSVNPYFARFDDDMM- 784  baker's yeast
19173015  227 YGTQFAIYRLGMSFKYKGTVRNQQCLA---------------LFQKKRKLLKEGEALVRSSTREGSAVYKVFVFDHLILi 291  Encephalitozoon c...
19115765  494 CVFHNIMQIHAVNSRLSNALNRTQTLQPVVNTIGDLFLDYVPKFEPFIKYGANQAIAKFEFEREKSTNRNFANYVHEVEr 573  fission yeast
19075616  668 TVFLNALEVQAVNSKLAEALTKRQNYKPIVDNIADIFLEHVPKFEPFIRYGAGQLYGKYEFEKEKSSNPAFAKFVSDVEr 747  fission yeast
1710634   511 HVFAHINEIYSVNREFLKALAQRQSLSPICPGIADIFLQYLPFFDPFLSYIASRPYAKYLIETQRSVNPNFARFDDEVS- 589  baker's yeast
1710635   785 -SSSLRHGIDSFLSQGVSRPGRYMLLVKEIMKSTDPekDKSDYEDLSKAMDALRDFMKRIDQASGAAQDRHDVKLLKQKI 863  baker's yeast
19173015  292 cDYPQNKFADLYINDEPIFMPRLIALKEDPGFFDKD-------E---D----FEEFSSLFLFEAGSAKAWGLYFHD---- 353  Encephalitozoon c...
19115765  574 lRESRKLELNGYLTKPTTRLARYPLLLSGVLKYTDK--DNPDTENIPRVIEMIREFLTKLNYETGKTENRLSLLQLNEQL 651  fission yeast
19075616  748 lKESRKLELNGYLTKPTTRLARYPLLLEAVLKYTDE--GNPDKQDIPKVINIVRGFLSRLNVESGKAENKFNLFHLNQQL 825  fission yeast
1710634   590 -NSSLRHGIDSFLSQGVSRPGRYSLLVREIIHFSDPvtDKDDLQMLMKVQDLLKDLMKRIDRASGAAQDRYDVKVLKQKI 668  baker's yeast
1710635   864 LFKN-EYVNLGLNDERRKIKHEGILSRKELSKSDGTVVGDIQFYLLDNMLLFLKAKAVNKWHQHKVFQRPIPLPLLFACP 942  baker's yeast
19173015  354 ---------QGERDVYFKIIQKAVHRVRAKLRDDISLR-TLPFETGETVRYACQANNT-DWRGESFSSSNSGEESSYMST 422  Encephalitozoon c...
19115765  652 SCSPaDRAKLTLFDPSRLLIFKGVVKLKASSYSNGDTENDIHMFLLDNFLLLCKIKIQMKRRVHKLHLRPLPLELLSISY 731  fission yeast
19075616  826 VFKPgEHYDLHLLDANRQLIFKGPLKKRSAGSTSSESASDVTLFLFDHALLIVKPKTINKRELLKVFQRPIPLLLLQLFL 905  fission yeast
1710634   669 LFKN-EYVNLGLNNEKRKIKHEGLLSRKDVNKTDASFSGDIQFYLLDNMLLFLKSKAVNKWHQHTVFQRPIPLPLLFICP 747  baker's yeast
1710635   943 GEDMPALRKYIGDHPdcSGTVIQPEYNTS---NPKNAITFLYYGAKQR-YQVTLYAAQYAGLQTLLEKIKQGQAAIISKT 1018 baker's yeast
19173015  423 DGDSLDSAEMLKPAG---CDSLDEAVNAF----------FENRNNSSK-DGEDPYEEDHDGSEDSLEPGSNK-----TWS 483  Encephalitozoon c...
19115765  732 IEDSPSRGSLPRRPS--SALLTNPISITKsnpPPVKAYGLQLVFIGARgFSISLYLNTLIARDQWKQHIEKQQDIIRKRH 809  fission yeast
19075616  906 VDDNGLRIPYSSKQQ---LAAVSKAANGK---PPSRFYPFSLQLLGRRgYEITLYATTEVSRDKWLEHIDNQQTLLQHRN 979  fission yeast
1710634   748 AEDMPPIKRYVTENPncSAGVLLPQYQTS---NPKNAIVFAYYGTKQQ-YQVTLYAPQPAGLQTLIEKVKQEQKRLLDET 823  baker's yeast
1710635  1019 EMFNVTKMSDRFFDy---TNKINSVTSCDGGRKLLIATNSGLYMSNIKRQQNKdhrhkssafFSTPIQLVQRNNITQIAV 1095 baker's yeast
19173015  484 LWKTLFPTADFFVS-----SIKLPLPLDRSNDPEYTSAQKSMYIIAVGDGVYRf--------FNQKIDRILERKVSKIIY 550  Encephalitozoon c...
19115765  810 LVFESRGICCQSWFt---GNKLLCAVAYDAGRKLLFGTYKGLYISSRKSNNGS---------CLEPIFKLQLPNISQLDV 877  fission yeast
19075616  980 QWFESVTICSNFFVg---DNKVNAIGVYDSGRRLLYGTDTGVYVSLRKANSPLq---------FKPVRALNIPNISQLEV 1047 fission yeast
1710634   824 KHITFKQMVGQFFHsyinTNRVNDVLICHAGKILLVATNMGLFVLNYATSINQ-----------KPVHLLHKISISQISV 892  baker's yeast
1710635  1096 LEEFKSIILLIDKKLYSCPLSLIEAEgngTSFFKKHHKELINHVSFFAEGDCNGKRLIVTAHSSSHSIKYFEHEHPLLAE 1175 baker's yeast
19173015  551 DSTYELMMYQSGSTLYASHFNVESTS---IEENVLKSDIENFFYGVTKQGPCIASTDSGDGKSVSIFLFLAVIS------ 621  Encephalitozoon c...
19115765  878 IEEHNVLLLLAEKILYELPLDALDSV---EQINSKSLRRVTGHVSFVKTGFCMQRILVCAVKSTVLNTTLRIYEADRALK 954  fission yeast
19075616 1048 IEEYSLLLLLSDKVLYSYPLEMIDAD---TTQAPKKARKVSGHTTFFRVGICLGKVLVCAVKSSVLSATIKVFEPVTNYS 1124 fission yeast
1710634   893 LEEYKVMILLIDKKLYGCPLDVIDDAenaDFLFRKNSKVLFKYVAMFKDGFCNGKRIIMIAHHFLHAAQLLIVN-PLIFD 971  baker's yeast
1710635  1176 KNGSGSgNKKSLKKK------ITEVIFDSEPVSISFLKANLCIGCKKGFQIVSISQNAHES------LLDPAD--TSLEF 1241 baker's yeast
19173015  622 -----N---EAVTIEl-----SRKLYVGLQVYNVFFCSEKIVIACRD-FEIVDMESLRTEE------LLQVYDpcIPVLF 681  Encephalitozoon c...
19115765  955 NKKTQS-LKKPFGNQatl-kiFTEVQMPMEALSVHFLKTKLCVGSFKGFDIISLENAVFQS------LLNPADt-SFRFL 1025 fission yeast
19075616 1125 KTRNMPsLKKFLTVNqdplriVKELYIPTESTSVHFLKNKLCVGCTRGFEVVSLDNLETQS------LLDPADt-SLEFV 1197 fission yeast
1710634   972 FN-SGN-FKKNLKAG------LVDFSVDSEPLSFSFLENKICIGCKKNIKILNVPEVCDKNgfkmreLLNLHDn-KVLAN 1042 baker's yeast
1710635  1242 ALRDTLKPMAIYRVGN-MFLLCYTEFAFFVNNQGWRKKESHIIHWEGEPQKFAIWYPYILAFDSNFIEIRKIETGELIRC 1320 baker's yeast
19173015  682 YGLKNTTARSILPVSPrEFLLCFDSVGFIVDDTGKLKRTDIIFLWNCRPVEFKLSKNYVICLGHRIINIFDLRTGLLIFT 761  Encephalitozoon c...
19115765 1026 EKREDIRPIAMFRLRG-EFLLCYSDFAFFVNTNGWKSRQSWMINWEGQPQGCALCYPYILAFEPDFIEIRNAETAELVQI 1104 fission yeast
19075616 1198 EKKENVKPIAIYRMNGgEFLLCYSQFAFYVNRDGWRSRPTWFVVWEGSPQNFALSYPYILAFEPTFIEIRHVETSELIHV 1277 fission yeast
1710634  1043 MYKETFKVVSMFPIKN-STFACFPELCFFLNKQGKREETKGCFHWEGEPEQFACSYPYIVAINSNFIEIRHIENGELVRC 1121 baker's yeast
1710635  1321 VLADKIRLLQT------STQEILY--CYEDYRGYDTVASLDFWG 1356 baker's yeast
19173015  762 KLQHGLRFVTGslepllHDGKNFYkiTFEADVDEANERSNKSHR 805  Encephalitozoon cuniculi
19115765 1105 IMGQNIKLLTDgrglisEGGEILYstEPIPFSSGENPIVHSLIL 1148 fission yeast
19075616 1278 ISGRNIRLLADgrgklgDGGEIFYa-CDQRGENCETSVVCSLRL 1320 fission yeast
1710634  1122 VLGNKIRMLKS------YAKKILY--CYEDPQGFEIIELLNF-- 1155 baker's yeast
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