Conserved Protein Domain Family
XRN_M

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pfam17846: XRN_M 
Xrn1 helical domain
This helical domain is part of the Xrn1 catalytic core. Xrn1 is a cytoplasmic 5'-3' exonuclease that degrades decapped mRNAs.
Statistics
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PSSM-Id: 375377
Aligned: 10 rows
Threshold Bit Score: 571.272
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_013755529        321 PWDDDNALDDFVFLCFFVGNDFLPHLPSLRIREGALDKLLRIYKEELP---------------KLDGHLTS--------N 377 
WGS:AAQB:GK24252-PA 328 AYDFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVY---------------KTQGYLTD--------S 384 
KRY50416            329 KYDFERCVDDWVFMCFFVGNDFLPHLPSLEIREGAIDRLVKLYKDCVY---------------RTGGYLTE--------N 385 
XP_002414458        320 TFNIERAIDDWVFMCFFVGNDFLPHLPSLEIREGAIDRLITLYKKAVY---------------KTGGYLTE--------N 376 
EQC33565            327 PYDFERIIDDFVFLCFFVGNDFLPHLPCMDIRDGAVDYLLLVYAKLLP---------------SLGGYITN--------P 383 
XP_004981452        322 KINFERLIDDFVFMCFFVGNDFLPHMPTLEIREGAINLLMSIYRAEFI---------------SMGGYLTD--------G 378 
CDY61133            296 QKKLDRIIDDFIFICFFVGNDFLPHMPTLEIQEVCFVLAFCCYNCVPGfkmlgtvydrsyitlASSRYLLK--------N 367 
KZN05342            276 QPDFERLVDDFIFICFFSGNDFLPHMPTLYIHEGCIDLLMHVYKKEFK---------------VFGGYLVDmqrandkkS 340 
XP_003606089        267 VFDLERIVDDFIFICFFSGNDFLPHLPSLYIHEDAIDLLMTVYKKEFS---------------KIGGYLVDi-------N 324 
XP_010095282        302 QFDIERIIDDFVFMSFFVGNDFLPRTPSLKVDE-----------------------------------IED--------S 338 
XP_013755529        378 --G-------ELILDRVQVIVDV------IGQMESDVFRDRKRNLDRAAMKAARRRGATASAAALERAGIAIMPTSGGKV 442 
WGS:AAQB:GK24252-PA 385 --G-------DVNLDRVQLIMTD------LGNAEDQIFKDRQRREKQFRDREKKKKQWERNDMKSLEQSVFGPQAVGAGK 449 
KRY50416            386 --G-------FVNLKRVQLIMSE------LGKVEDEIFRQRQEREAMNNIFFIGLAESFDAPAFIPQNAFAPTPIGESPL 450 
XP_002414458        377 --G-------FVALERVQLIMSGkcgfslLLAVGQAVGATQNARREAYDMRREGMEHRRNLSTGNLAANGPLESM----- 442 
EQC33565            384 g-G-------EIDLSRADVLLAE------VGTVEETIFQRRIEKERRNVEFQARREMYKKRDQVAAEAARGDAVSVKRHK 449 
XP_004981452        379 --G-------EVVLDRVEHFIQS------VAFNEEQIFQKRARIQQARENNEERN------------------------- 418 
CDY61133            368 --Rtqs--srNCNYDPVVQLDSL------VEVS------------DSLRPSFDNNTSVANVETYFLTEYSI--------- 416 
KZN05342            341 --G-------YIKLKRVEKFILL------VGNYEENIFRKRADQRGRMLRKILKEYEDSRFDDENQDVGTSELHLSTLRI 405 
XP_003606089        325 --KigekhgaYVKLSRVEKFVLM------VGTYEEKIFSKRTAIRDKKLRRLISDNENSKQEELNSHDCMDFDNENSSNC 396 
XP_010095282        339 egG-------YIELSRVERFVSL------VGSYENKIFRKRSHLEDRKPKRLLLTSNALEEDDTDDSMTNATNK------ 399 
XP_013755529        443 AkaaamessagegevepvpmeeekgeaqmkvetgaateteaeAEIEAEADAEADAEADAETEVEAEAETEVEDNESDGAD 522 
WGS:AAQB:GK24252-PA 450 G-----------------------------------------DGPTNIQNYKAEAAALRLGQKRSGADAGLQAEEEDEDC 488 
KRY50416            451 Pl---------------------------------------sNAKRTAMEMRQAAMAVTTSTKREFNGAANAEDANDEGP 491 
XP_002414458        443 -------------------------------------------------LRPVSVRSSAPSSPHPSLGHEGDDSSDEEEP 473 
EQC33565            450 Dg---------------------------------------rGVATPSNEVYTQLEPKQALKERIKQMEQAKLDKYRDEI 490 
XP_004981452        419 --------------------------------------------------------------------KIQRESTEENQY 430 
CDY61133            417 ----------------------------------------------------FVTFGWIVVDLCDYNLCLLDGFSSGKGE 444 
KZN05342            406 Sgnfse-------------------------------dlhtsANGVNDPELILRNTKELKDKLREYIWKAADSFQNGGLG 454 
XP_003606089        397 Alrikk--------------------------------aeasDNVCPQSDEEILKNTKDLKEKLKKCIKDKGDLFKSGDF 444 
XP_010095282        400 -------------------------------------------------LSTYSNLLKNTNELKEKVKENLRNSGLYGDG 430 
XP_013755529        523 -LDQVRLWEEGWKKRYYKAKFEV--DLERNAlFRRE-LARAYVQGLVWVYRYYYQGCCSWRWF-YPYHYAPFASDLSSLA 597 
WGS:AAQB:GK24252-PA 489 -NDEVRLWEDGFKNRYYESKFDV--GPDNLQ-FRYA-VALQYVRGLCWVLKYYYQGCSSWNWY-FPYHYAPFASDFVNIQ 562 
KRY50416            492 -LDEVRLWECGWKDRYYLVKFQC--SPKDLK-FRHH-VANCYVEGLCWVLRYYYQGCCSWKWY-FPFHYSPFASDFMNIG 565 
XP_002414458        474 -HDEVRLWEDGWKERYYVSKFDI--NSDNVA-FRHE-VATAYVEGLCWVLRYYYQGCASWKWF-FPYHYAPFASDFINVG 547 
EQC33565            491 -KDTVRLGEPGWKTRYYEDKLKA--NDIEIG-GGRErVFQAYIEGLCWVMRYYYAGCVSWTWF-YPFHYAPFASDLKNID 565 
XP_004981452        431 -VDKVKLGEPGYRERYYAEKFKEeaESKPID-QVRRdVVQKYVEGLCWVMRYYYQGVCSWQWF-YPYHYAPFASDLKDLA 507 
CDY61133            445 -EDKVRLGVQGWRERYYEEKFIAk-TIEEME-QICRdVVLKYTEGLCWIMHYYYHGVCSWNWSvYPYHYAPFASDLKFLD 521 
KZN05342            455 -SDKVKLNLPGYRDRYYMEKFELt-STVDIE-QIRRsVVEKYTEGLCWVTLYYFAGVPSWTWY-YPYHYGPFASDMKGLS 530 
XP_003606089        445 lTDKIKLGNVGFKERYYKEKFSVegSTNIEL-KRKE-IVQKYTEGLLWVLQYYFSGVASWTWF-YPYHYGPFVSDLKGMA 521 
XP_010095282        431 -VDRVRLGATGYKERYYKERFSEk-YRGDIE-TIRKdIVVKYTEGLLWTLLYYFQGPPSWTWY-YPYRAGPFVSDLKGLS 506 
XP_013755529        598 DFegELEFDR-GTPFTPLTQLMAVLPPASKDALPAPYQRLMTES---DSPIVHFY--PDTFGLDLNGHRASWMAVVLLPF 671 
WGS:AAQB:GK24252-PA 563 GL--STLFEKgTKPFNPLEQLMGVFPAASSSHVPQPWVELMSSP---TSPIIDFY--PEDFKIDLNGKKFAWQGVALLPF 635 
KRY50416            566 DL--KIDFSEkTMPIKPLEQLMSVFPAASSKHLPKSWAALMHDPvrdKSTIIDMY--PSDFKVDLNGKRYAWQGVVLLPF 641 
XP_002414458        548 DI--KINFERdTQPFKPMEQLMSVFPAASKQHLPPAFGDLMDDP---DSPIIDFY--PIDFKIDLNGKKYAWQGVALLPF 620 
EQC33565            566 RY--EIKFDL-GQPFCPFEQLMGVFPADSKHAIPKPYQWLMTDP---ESPILDFY--PEEIPLDPNGKPVPWLWIALLPF 637 
XP_004981452        508 EL--EITFFL-GQPFKPFDQLMGTLPAASSNALPKYYGDLMTDP---NSPLKSFY--PKDFEIDMNGKRFAWQGVAKLPF 579 
CDY61133            522 KL--YIKFEL-GSTFKQFNQLLAVLPSASAHALPECFRKLMTDP---SSPIAELY--PPDFEIDMNGKRYSWQGIAKLPF 593 
KZN05342            531 QV--KLHFQK-GLPFKPFEQLMGVFPPRSAHALPIPYQKLMKDE---DSSIIDFYqtGQDFQIDVDGTRHTWQGICKLPF 604 
XP_003606089        522 QV--RVNFEK-GVPFLPFDQLLSVLPQKSAYALPKAYAQLMLDE---QSKIFDLY--SQDFEIDIEGKRFMWQGVCKLPY 593 
XP_010095282        507 QI--KIRFEK-GSPLKPIENLMAIIPLSGVFALPKAYQALMKE----DSPIIDPEs-CYEIERVIEGKRC----VCQVPV 574 
XP_013755529        672 IEEQALLEALASVDGELSPAERARNTPKREVIFVHAANAKVYp------FVARAYAQGs--DGAKLLID--------VAG 735 
WGS:AAQB:GK24252-PA 636 VDEKRLFKALVPFYEQLTSEEVKRNKRGNNYLYISKESPHFK-------VANKIYRQKk--DDEVAQFDeeegypisLDG 706 
KRY50416            642 VDAERLNEALEVVYPDLTEEERFRNRQGNDLLFISSKHEAFD-------FIQSIYEGDm--NAEWLNMDps-----lCNG 707 
XP_002414458        621 VDERRLLETVKTVYPTLTEDEVKRNIRGDDVFYVRKGHRGYSy------LLGLYEACK---DFNr-----------vSTL 680 
EQC33565            638 IDEKRLLDAMAPMNAKLTNAEKKRNERFGKELIFFHANANQ------------PLPTP---TNSPVALVp------aTFE 696 
XP_004981452        580 IDETRLLAETRKLEDTLTEEEKFRNTTMFDIIYVRETHPLTAqi----aFLYRMYNHLprtDPYVIPIDpa-----aSGG 650 
CDY61133            594 IEEQRLLDAAAKMEHSLTNEEVRRNNVLSDMLFVVLSYPLAElirslssRTIKLSNKEr--ATVKEKIDhg-----lSEG 666 
KZN05342            605 IEESRLLAETRKLECELQADEVIRNSEGLDMLFLGRTSSEIIc------DRQNVDSNE---HFHERNIDak-----lSHG 670 
XP_003606089        594 MDEKRLLTETRELKNELSESEAKRNSVEVDRLLVSGTTKLAEk------ICSLKL------NKLDTSIS--------SDG 653 
XP_010095282        575 IDEGRLLSEARKLENDLQDEEKERNTQRLDQLLVRCTHKLGS-------LILSFSEEQ---NEVKRAis-------lSDE 637 
XP_013755529        736 MGGQAFAAaEpLAQVGTDLA-PPAEf--dRWPSIRRNAVVVADFEFPSPpydDYVHEAVVLPGS----IFPPQAL-TEMD 807 
WGS:AAQB:GK24252-PA 707 MRGTINRT-ElSTAINAILQ-SPIG----DLPDITDNQILTTTFNDPQYd-eDYIFPAKRLPKA----VDPPQVL-SPED 774 
KRY50416            708 ISLMVKPY-KfHVPVGKTVH-SPLP----QCNDVENNHVLSVFCLNPQFp-dDYIFSTARLSGAcclfRDPQPVL-KPKD 779 
XP_002414458        681 IPAHLRCS-E-EFLCFSIFS-SDVHsvirGLDNIPDNSVVCVRFRDPKYg-nDYVFKAERLPGA----KDPDRVL-KPGD 751 
EQC33565            697 MAGSMAYH-EpSFFPEGCIVpSPEKak-iELLDIRNNKCLSFEFLSPPK---N-RHLSVLLPGA----IEDEPVLvTPED 766 
XP_004981452        651 MNGFLCLS-E-RNWYSITVT-SPVK----CFNGIAQNRVLNATYLNPQY---H-KHIPEPPVGV----IVPGKIL-KPSD 714 
CDY61133            667 MNGYLAIH-A---------S-APPSr---GMEDVLANQVICAIYKLPDDl--RGSDIARPPPGV----VLPKKTV-QLAD 725 
KZN05342            671 LNGSVLLK-E-ENVADK------L--------SLYDNDILCVFYKLPPH---R-MHYPRKLEGV----VVPEETI-TEAD 725 
XP_003606089        654 IGGIISLC-H-ECVENNK----------------HEDIVFCVKYEHPVG---GTSHVQHLLCGV----NLPEKTI-FEND 707 
XP_010095282        638 IGGFIWLPlE-NTVTGNHVC-----------NNNEDDSVLCVFYELPND---D-PHIPCLVSRV----KCPNKIV-SESD 696 
XP_013755529        808 L 808 
WGS:AAQB:GK24252-PA 775 H 775 
KRY50416            780 W 780 
XP_002414458        752 L 752 
EQC33565            767 R 767 
XP_004981452        715 F 715 
CDY61133            726 L 726 
KZN05342            726 V 726 
XP_003606089        708 I 708 
XP_010095282        697 I 697 
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