Conserved Protein Domain Family
FtsH_ext
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pfam06480: FtsH_ext 
FtsH Extracellular
This domain is found in the FtsH family of proteins. FtsH is the only membrane-bound ATP-dependent protease universally conserved in prokaryotes. It only efficiently degrades proteins that have a low thermodynamic stability - e.g. it lacks robust unfoldase activity. This feature may be key and implies that this could be a criterion for degrading a protein. In Oenococcus oeni FtsH is involved in protection against environmental stress, and shows increased expression under heat or osmotic stress. These two lines of evidence suggest that it is a fundamental prokaryotic self-protection mechanism that checks if proteins are correctly folded (personal obs: Yeats C). The precise function of this N-terminal region is unclear.
Links
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Statistics
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PSSM-Id: 377663
Aligned: 157 rows
Threshold Bit Score: 31.8053
Created: 22-Mar-2022
Updated: 13-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9SLX5            160 WLFQLLLAGGIFYALNSGEgnd------------ssGSGTG--------------------MRREINFqqfvrdllepgl 207  Cyanidios...
Q5KKS9             87 PLTPFQARVAELEIKAHANkedpdaqleflrqlsegGEFAGlvayyegmalaedtsgsqalLRNDEAWaifmdalarsgr 166  Cryptococ...
Q9RVK7             24 GLLTLHLLTLPVLVQGTAAattahvtasanapttpaPQPPTwtpnk----------gnprlMPENYTVnr---------f 84   Deinococc...
Q3Z9G3             13 TIIYIVMLVAIIAIFSFLVpn--------------------------------------sqKPEEVPLsq---------i 45   Dehalococ...
Q1GSR0             16 VMIWSGILLAMLLVASMFGgaa-------------------------------------qpVGNPLAYse---------f 49   Sphingopy...
A1TZE0             25 SFLWLSAAIFLMFLWLQGNnq---------------------------------------qQQQELAYse---------f 56   Marinobac...
WP_007224876       36 VLTWVLVVSSLMYLWTNVTt----------------------------------------qPYHSIPYsd---------f 66   marine ga...
jgi:Franean1_1984  39 FLIPVGLLVTVMLLIAPSLfa---------------------------------------tQPDSLTYsd---------f 70  
A0LR74             28 WLLPIGLLVSLVLLFTFPMrp---------------------------------------sSGKTLTYse---------f 59   Acidother...
WP_002648335       35 PWLIILLILVIGSLMLMK------------------TSPEN--------------------TGSKVDYsf---------f 67   Gimesia m...

Q9SLX5            208 VDHLEIVNRQTAYVYvkqtyqgepskRSAGSrqtaedvvldtgvdqpqrdalwetsaqpqltgedysgsesppaairrpr 287  Cyanidios...
Q5KKS9            167 LGDIVTKVRRRDQLLasiganggsss---------------------------------------------saplvsnpt 201  Cryptococ...
Q9RVK7             85 FADLQAGKVERVKLDga--------------------------------------------------------------- 101  Deinococc...
Q3Z9G3             46 ITLSQEHKIAEITVD----------------------------------------------------------------- 60   Dehalococ...
Q1GSR0             50 RQKVEEGSVKEVILS----------------------------------------------------------------- 64   Sphingopy...
A1TZE0             57 KQAVISGQVAEVTLRteeisgs-----------------------------------------------------ftdsg 83   Marinobac...
WP_007224876       67 KQELISDNIEQISVKeseing-------------------------------------------------------sfri 91   marine ga...
jgi:Franean1_1984  71 VGRVDSGVVRSVTIDdr--------------------------------------------------------------- 87  
A0LR74             60 LTALHHHDIKTITIHsd--------------------------------------------------------------- 76   Acidother...
WP_002648335       68 ISELKRGNVDSVDFH-----------GDILTgkwk-------------------------------------------tk 93   Gimesia m...

Q9SLX5            288 gdGVS-DSKRLNRPTVMYYFTLGSVesferkLEQAEKSLGIDPIPVVF 334  Cyanidioschyzon merolae
Q5KKS9            202 psSVS-ANNSSTSTPSVSSPGPSLTssllsrAVSPTSLANASNASTSQ 248  Cryptococcus neoformans
Q9RVK7            102 gnTQV-FFKEPAGGPNPRWLLLPPDaatlarLRGSGVTMQVTPGGSRF 148  Deinococcus radiodurans
Q3Z9G3             61 --SENiEVTTTDGTKLSTVKEYIASiydiegLDLTDVKVNIQPAGGLD 106  Dehalococcoides mccartyi 195
Q1GSR0             65 ---ED-RVTGTLSNGDRFTANVVRDpdllkmLNDNGVKYDGQPAETPN 108  Sphingopyxis alaskensis
A1TZE0             84 asRFA-NDSRPPSSSFITLRPQVEDpellplLERQEVLVRGSRSGRPW 130  Marinobacter nauticus VT8
WP_007224876       92 giSDE-DKPANIHQRFRTIVPSFGDtelltlLESKQVAIQSIAATTPL 138  marine gamma proteobacterium HTCC2143
jgi:Franean1_1984  88 -gGVD-GTLTDGTDFTTQIPTALDTtalerqLAAKKVQITATRTGTSF 133 
A0LR74             77 -gEAS-GQFADGRPYSTTIPIGLAGsqllneLENNGVQISARPPGPSL 122  Acidothermus cellulolyticus 11B
WP_002648335       94 peNPD-KEKKDEKLAEEFNTVLPSHpvedrnLIPELEKQGVTFKAEST 140  Gimesia maris
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