6N9O,6VIE


Conserved Protein Domain Family
Gasdermin_C
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pfam17708: Gasdermin_C 
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Gasdermin PUB domain
The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein
Links
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Statistics
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PSSM-Id: 407590
Aligned: 14 rows
Threshold Bit Score: 160.986
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6N9O_D       285 TEDFQGLRAE---VETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLG----------PVEPLDGPAG 351 human
Q29S10       287 TDDYQGLRAE---VKAWAMGLEGLSKGLCGQLLGGLGQVLRDEPALQALEDSLEQGLCSG----------PVEPRDGPVG 353 cattle
Q9Z2D3       279 DGPLRVVKQAtlhLERSFHPFAVLPAQQQRALFCVLQKILFDEELLRALEQVCDDVAGGLwssqavlameELTDSQQQDL 358 house mouse
6VIE_D       263 AADFQGLYAE---VKACSSELESLEMELRQQILVNIGKILQDQPSMEALEASLGQGLCSGg---------QVEPLDGPAG 330 house mouse
Q9BYG8       313 WQNFKHLQEE---VFQKIKTLAQLSKDVQDVMFYSILAMLRDRGALQDLMNMLELD--------------SSGHLDGPGG 375 human
Q2KJ26       296 SRDFKSLQNE---VSREIEAVAELPRDIRDALFHTILAKLKDQGALQDLTDMLD------------------GNLWDHTG 354 cattle
Q96QA5       254 HEGFRTLKEE---VQRETQQVEKLSRVGQSSLLSSLSKLLGKKKELQDLELALE------------------GALDKGHE 312 human
Q32M21       252 HEDFKTLKKE---VQQETQEVEKLSPVGRSSLLTSLSHLLGKKKELQDLEQMLE------------------GALDKGHE 310 house mouse
XP_015136931 287 HASLSVLKKDlsqLKAQFQPFVKLPEDKQRALYKSLCELLLHEETLTALEDVLDALCTGDkpd-----lkELKPAQQQDL 361
O60443       279 DGPLSVLKQAtllLERNFHPFAELPEPQQTALSDIFQAVLFDDELLMVLEPVCDDLVSGLsptv--avlgELKPRQQQDL 356 human

6N9O_D       352 AVLECLVL----------SSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPwqerst 421 human
Q29S10       354 AILESLVL----------PSGQLETELAGPVFYLLQALAVLSEAQHVLLAEVLEMGALSGTFWLVESLVEQSSPwqehra 423 cattle
Q9Z2D3       359 TAFLQLVGyriqgehpgpQDEVSNQKLFATAYFLVSALAEMPDNATVFLGTCCKLHVISSLCCLLHALSDDSVC------ 432 house mouse
6VIE_D       331 CILECLVL----------DSGELVPELAAPIFYLLGALAVLSETQQQLLAKALETTVLSKQLELVKHVLEQSTPwqeqss 400 house mouse
Q9BYG8       376 AILKKLQQ----------DSNHAWFNPKDPILYLLEAIMVLSDFQHDLLACSMEKRILLQQQELVRSILEPNFRypwsip 445 human
Q2KJ26       355 SFLSEMRE----------DSRNVWLESRPCVIYLLEALLVLSDIQHELLAWSMEKRILPQQRELVESILEPNFRypwnip 424 cattle
Q96QA5       313 VTLEALPK-----------DVLLSKEAVGAILYFVGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLldkegv 381 human
Q32M21       311 VTLEALPK-----------DVLLLKDAMDAILYFLGALTELSEEQLKILVKSLENKVLPVQLKLVESILEQNFLqdkedv 379 house mouse
XP_015136931 362 ADFLQLVGcrvqdelllqNYHLQDEELLSAAHLLISAISELSDYTLVLLRACSDLQVVPALCCLPYIASADGTL------ 435
O60443       357 VAFLQLVGcslqg-gcpgPEDAGSKQLFMTAYFLVSALAEMPDSAAALLGTCCKLQIIPTLCHLLRALSDDGVS------ 429 human

6N9O_D       422 mSLPPGLLGNSWGEG--APAWVLLDECGLELG--EDTPHV 457 human
Q29S10       424 vSLPPERLGDSWGSE--APGWALLEACGLEPQ--VGTPQV 459 cattle
Q9Z2D3       433 -DFHNPTLAPLRDTErfGIVQRLFASADIALErmQFSAKA 471 house mouse
6VIE_D       401 vSLPTVLLGDCWDEK--NPTWVLLEECGLRLQ--VESPQV 436 house mouse
Q9BYG8       446 fTLKPELLAPLQSEGl-AITYGLLEECGLRME--LDNPRS 482 human
Q2KJ26       425 fTLDPKLLASLQDEGl-AVTFGLLQECGLRVA--PDNPKG 461 cattle
Q96QA5       382 fPLQPELLSSLGDEEl-TLTEALVGLSGLEVQ--RSGPQY 418 human
Q32M21       380 fPLRPDLLSSLGEEDq-ILTEALVGLSGLEVQ--RSGPQY 416 house mouse
XP_015136931 436 -ALSSPSVATLTDRRrfDVAQRLFASANINLEktETSVKA 474
O60443       430 -DLEDPTLTPLKDTErfGIVQRLFASADISLErlKSSVKA 468 human
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