Conserved Protein Domain Family
GAIN_A
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pfam18619: GAIN_A 
GPCR-Autoproteolysis-INducing (GAIN) subdomain A
GPR56 is a a cell-surface G protein-coupled receptor (GPCR) which belongs to the adhesion G protein-coupled receptor (aGPCR) family, a large family of chimeric proteins that have both adhesion and signaling functions and play critical roles in diverse neurobiological processes including brain development, synaptogenesis, and myelination. This entry represents GPCR-Autoproteolysis-INducing (GAIN) subdomain A, including PLL-GAIN linker (F161-D175) region.
Links
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Statistics
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PSSM-Id: 436625
Aligned: 12 rows
Threshold Bit Score: 81.7492
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_017197735 173 SGDMCELKRDLQLLSQLLRHPQKAAR-------RPSSSlaHRKLQSLESKLASVR 220
XP_012396159 178 SVDMCDLKRELQSLSVLLSNPGKAGR-------KPASN--SKHLQNLESKLVGVH 223
XP_006255128 173 SVNMCDLKKELQLLSKFLQHPHKASK-------RPSAAfiSQQLQNLESKLTSVS 220
Q50DM6       173 SVDMCELKRDLQLLSQFLKHPQKASR-------RPSAApaRQQLQSLESKLTSVR 220 western lowland gorilla
XP_010637182 173 SVDMCELKRDLQQLSQILRLPQKASR-------KSPATfaSQQLQSLESKLSLVR 220
EHB00663     173 SVDMCELKRDLQRLSQLLRKPRAGSR-------PP--LpaSEQLQSLESKLSSVR 218
ELK15423     173 SVDMCELKRDLQLLSQLLKHPRKNSR-------KPSATaaSHRLHSLESKLTSVR 220
XP_010594361 172 SVDICELKRDLELLSKLLKHPRKSSR-------RPSSTpaRQHLQSLESKLTSMR 219
XP_544387    173 SVDLCELKRDLEQLSQLLKHPGRTSR-------KPSSTpaSQRLQTLESRLTSVK 220
XP_020948992 175 SVDICELKRDLQLLSQLLKHPQKTSR-------RHQFIpaSQRLQSLESKLTSVS 222
XP_012012231 187 SVDVCELKRDLQRLSQFLKHPQKTSR-------RPPFTpmGQQLQSLESKLASVN 234
XP_013221796 170 SWDMCDLKRDLGMLSRLLKQPLKSPRrpsllpaRQ--------LQSLESKLAAVS 216 thirteen-lined ground squirrel
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