Conserved Protein Domain Family
HR1

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cl00087: HR1 Superfamily 
Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
The HR1 domain, also called the ACC (anti-parallel coiled-coil) finger domain or Rho-binding domain binds small GTPases from the Rho family. It is found in Rho effector proteins including PKC-related kinases such as vertebrate PRK1 (or PKN) and yeast PKC1 protein kinases C, as well as in rhophilins and Rho-associated kinase (ROCK). Rho family members function as molecular switches, cycling between inactive and active forms, controlling a variety of cellular processes. HR1 domains may occur in repeat arrangements (PKN contains three HR1 domains), separated by a short linker region.
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Accession: cl00087
PSSM Id: 469609
Name: HR1
Created: 8-Feb-2008
Updated: 4-Oct-2023
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