Conserved Protein Domain Family
TOPRIM

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cl00718: TOPRIM Superfamily 
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Links
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Taxonomy: root
PubMed: 43 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl00718
PSSM Id: 469888
Name: TOPRIM
Created: 8-Feb-2008
Updated: 4-Oct-2023
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