2CKK


Conserved Protein Domain Family
KN17_SH3
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pfam18131: KN17_SH3 
KN17 SH3-like C-terminal domain
This domain can be found at the C terminus of the human KIN17 protein and its homologs. In human cells, over-expression of KIN17 modifies the nuclear morphology and inhibits S-phase progression, thus blocking cell growth as part of the response to genotoxics. The C-terminal domain exhibits an all-beta structure consisting of two tightly packed SH3-like subdomains. It binds to RNA and is generally well conserved. This domain has structural similarity with various SH3-like domains, although it lacks similarities in both primary sequence and charge distribution.
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Statistics
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PSSM-Id: 407963
Aligned: 7 rows
Threshold Bit Score: 73.5346
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2CKK_A    10 RTDYWLQPEIIVKIITKKLGE-K-YHKKKAIVKEVIDKYTAVVKMID-SGDKLKLD 62   human
EFA76803 314 KVESWIARNIVVKIMEKSIGNgK-FYKQKALIEELDSEYVAKVKTLE-DNTVLKID 367 
VDM34400 329 RKDYWMTVGIEVKLTYYKLPK-D-LLYRHAVIIDMEDDYTALVQVLGsSKAKLKVD 382 
KRZ04948 807 RTDCWLHPGIVVKIISKRYGE-R-LNNEKGVIINVKEERFACLQLLSdEDTTVTVD 860 
VDD66061 277 RKPYWLFQGIVVKVMSKALAD-KgYYKQKGVVRKVIDDYVGEIEMID-SKHVLRVD 330 
KDO30767 281 RKDHWVAKDIVVKIVDKKVGDgA-YYKKKGTVPKVIELFGADIKVHD-SGDIVRVD 334 
ESS30671 391 NKDWWIKEGCIVKVMHAELGDgQ-YYKQKGKILRVEERYAAYVKMLE-SGDLIRLD 444
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