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AAC(6')-Iy/Iaa family aminoglycoside 6'-N-acetyltransferase Members of this family are chromosomal acetyltransferases from the genus Salmonella. Analysis has demonstrated a case in which a member designated AAC(6')-Iy, identical in two different strains isolated from a single patient, conferred resistance to tobramycin only in the isolate where a deletion event upstream of the gene resulted in high expression. Members of this family are therefore considered cryptic aminoglycoside N-acetyltransferases. which may or may not confer resistance, depending on expression levels. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",