Conserved Protein Domain Family
KH-I

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cl00098: KH-I Superfamily 
K homology (KH) RNA-binding domain, type I
KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that belong to different protein folds, but they share a single KH motif. The KH motif is folded into a beta alpha alpha beta unit. In addition to the core, type II KH domains (e.g. ribosomal protein S3) include an N-terminal extension and type I KH domains (e.g. hnRNP K) contain a C-terminal extension. Some KH-I superfamily members contain a divergent KH domain that lacks the RNA-binding GXXG motif. Some others have a mutated GXXG motif which may or may not have nucleic acid binding ability.
Links
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Taxonomy: root
PubMed: 596 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl00098
PSSM Id: 469614
Name: KH-I
Created: 8-Feb-2008
Updated: 4-Oct-2023
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