Conserved Protein Domain Family
MAGUK_N_PEST
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pfam10608: MAGUK_N_PEST 
Polyubiquitination (PEST) N-terminal domain of MAGUK
The residues upstream of this domain are the probable palmitoylation sites, particularly two cysteines. The domain has a putative PEST site at the very start that seems to be responsible for poly-ubiquitination. PEST domains are polypeptide sequences enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) that target proteins for rapid destruction. The whole domain, in conjunction with a C-terminal domain of the longer protein, is necessary for dimerization of the whole protein.
Links
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Statistics
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PSSM-Id: 431391
Aligned: 19 rows
Threshold Bit Score: 52.4637
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q28C55       107 KYRYPDDDI-TSQEPSSPHMLNDGR------NVELVQISEKNISQKENI-------QGLVSHSLISPLK----------- 161  tropical clawe...
Q62936        27 PPGYGDWQVpDPYGPSGGNGASSGY-------------------------------GGYSSQTLPSQAGatptpr--tka 73   Norway rat
Q6ZSU2        43 GLGYSSQTM-PSSGPGGPA-SNRTGgs--sfNRTLWDSVRKSPHKTSTKgkgtcgeHCTCPHGWFSPAQ----------- 107  human
8_pfamImport   1 GYFYNSQTL----QSSGSTLARSRGklstmrSESIWKSPSKSVAKGKGAnse-wwsDCSCPHGWHDSYQ----------- 64  
XP_005997201  96 KHKCQDEDS-LISDIRLPKYAESAQsf--sqDPELVTVTSRSTELKESI-------YSVVSHSHIALPK----------- 154 
XP_006637474 107 KYRYQDEDT-PPQEHSSPHLASEAK------GPELVHVSEKNLSQIENV-------HGFVSHSHISPMK----------- 161 
Q5PYH5        35 KYRHQDEDTgSPQEPSSPQFTDDTP------GPELVQVAEKSLSQIENV-------HGFVAHSHISPMKveslecifdgp 101  zebrafish
2_pfamImport   1 KYRHHDEDS-SPQDQSSPQLTEEAG------GPELVQVAEKNLSQIENV-------HGYVTHAHISPMKvgd-------- 58  
XP_009295246  90 KYRHQDEDTgSPQEPSSPQFTDDTP------GPELVQVAEKSLSQIENV-------HGFVAHSHISPMK----------- 145  zebrafish
PNJ07473     107 KYRYQDEDT-PPQEHISPQITNEVI------GPELVHVSEKNLSEIENV-------HGFVSHSHISPIK----------- 161  Sumatran orang...

Q28C55       162 ---Tpeadtpcppivpvipv----------ipvpaesnvipsstpqANPPPVIVNTD-LETPAYVNGTDAEYEYE 222  tropical clawed frog
Q62936        74 kliPtgrdvgpvppkpvpgkntpklngsgpswwpectctnrdwyeqASPAPLLVNPEaLEPSLSVNGSDGMFKYE 148  Norway rat
Q6ZSU2       108 ----------------------------------------------ASPAPIIVNTDtLDTIPYVNGTEIEYEFE 136  human
8_pfamImport  65 ----------------------------------------------ASPAPIIVNTEtLDTVPYVNGTEIEYEFE 93  
XP_005997201 155 ----------------------------------------------AKPPPIIVNTDsLEHDPYVNGTDGVYKYE 183 
XP_006637474 162 ---Qtdavppcapvipvipl----------spvpaettvisppasqANPPPVVVNTDsLDTPPYVNGTEADYEYE 223 
Q5PYH5       102 spvVkeesppspstpl------------------snpypqspvsvqANPPPVVVNTEsLDSAPYVNGTEADFEYE 158  zebrafish
2_pfamImport  59 gtvSasrlshwskhlp------------------vcrrlywllfqtANPPPVVVNADsLDTPPYVSAGNSGLGFS 115 
XP_009295246 146 ---Qtdavppstliipvipi----------stvptepavispstsqANPPPVVVNTEsLDSAPYVNGTEADFEYE 207  zebrafish
PNJ07473     162 ---Pteavlpcpptapvipa----------lpvpaestvilpaipqANPPPVLVNTDsLETPTYVNGTDADYEYE 223  Sumatran orangutan
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